Archives of Gynecology and Obstetrics

, Volume 272, Issue 2, pp 167–172

Vulvar susceptibility to contact irritants and allergens: a review

Original Article


Vulvar tissue differs from cutaneous epithelia in structure, morphology and biophysical characteristics. For example, the skin of the labia majora exhibits elevated hydration, occlusion and frictional properties, which may increase susceptibility to irritants and contact sensitizers. Furthermore, the nonkeratinized vulvar vestibule is likely to be more permeable than keratinized regions. These differences heighten vulvar susceptibility to topical agents. This reviews the structure and properties of vulvar tissue, emphasizing their impact on susceptibility contact irritants and allergens.


Vulvar epithelium Keratinization Permeability Irritant contact dermatitis Allergic contact dermatitis 

Copyright information

© Springer-Verlag 2005

Authors and Affiliations

  1. 1.Feminine Care and Family Care Research and DevelopmentThe Procter & Gamble CompanyCincinnatiUSA

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