Hormonal alterations in gum disease leading to preterm labor
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Most studies concerning the relationship between oral infection and systemic diseases are related to periodontal disease (gum disease), by far the most common oral infection. The term periodontal disease is used to describe a group of conditions that cause inflammation and destruction of the attachment apparatus of the teeth. Gum disease is caused by bacteria found in dental plaque and about ten species have been identified as putative pathogens in periodontal disease, mainly gram-negative rods. Actinobacillusactinomycetemcomitans, Porphyromonas gingivalis, Treponemadenticola, and Tanerella forsynthesis are the gram-negative bacteria most commonly associated with mature plaque and progressing periodontitis . Furthermore, Prevotella intermedia, Streptococcus intermedius-complex, Peptostreptococcus micros, Fusobacterium nucleatum, Eubacterium nodatum, and Campylobacter rectus have shown moderate evidence for the disease etiology .
Periodontitis lesions exhibit gingival...
KeywordsPreterm labor Gum disease Cytokines Prostaglandines
- 6.Gemmell E, Grieco DA, Cullinan MP, Westerman B, Seymour GJ (1999) The proportion of interleukin-4, interferon-gamma and interleukin-10-positive cells in Porphyromonas gingivalis-specific T-cell lines established from P. gingivalis-positive subjects. Oral Microbiol Immunol 14:267–274PubMedCrossRefGoogle Scholar
- 10.Hasegawa K, Furuichi Y, Shimotsu A, Nakamura M, Yoshinaga M, Kamitomo M, Hatae M, Maruyama I, Izumi Y (2003) Associations between systemic status, periodontal status, serum cytokine levels, and delivery outcomes in pregnant women with a diagnosis of threatened premature labor. J Periodontol 74:1764–1770PubMedCrossRefGoogle Scholar
- 11.Hauth JC, Saber M (2000) Periodontal diseases and their systemic implications. Lectures at the 7th Annual meeting of IAMA, BostonGoogle Scholar
- 20.Lin D, Smith MA, Champagne C, Elter J, Beck J, Offenbacher S (2003) Porphyromonas gingivalis infection during pregnancy increases maternal tumor necrosis factor alpha, suppresses maternal interleukin-10, and enhances fetal growth restriction and resorption in mice. Infect Immun 71:5156–5162PubMedCrossRefGoogle Scholar
- 21.Loesche WJ (1994) Ecology of the oral flora. In: Nisengard R, Newman MG (eds) Oral microbiology and immunology, 2nd edn. WB Saunders, Philadelphia, pp 307–319Google Scholar
- 22.Loesche WJ (1997) Association of the oral flora with important medical diseases. Curr Opin Periodontol 4:21–28Google Scholar
- 28.Miller WD (1891) The human mouth as a focus of infection. Dent Cosmos 33:689–713Google Scholar
- 31.Offenbacher S, Madianos PN, Suttle M et al (1999) Elevated human IgM suggests in utero exposure to periodontal pathogens. J Dent Res 78:2191–2193Google Scholar
- 34.Romero R, Baumann P, Gomez G, Salafia C, Rittenhouse L, Barberio D, Behnke E, Cotton DB, Mitchell MD (1993) The relationship between spontaneous rupture of membranes, labor, and microbial invasion of the amniotic cavity and amniotic fluid concentrations of prostaglandins and thromboxane B2 in term pregnancy. Am J Obstet Gynecol 168:1654–1664PubMedGoogle Scholar