Archives of Gynecology and Obstetrics

, Volume 272, Issue 4, pp 273–277 | Cite as

Chromosome inversions and a novel chromosome insertion associated with recurrent miscarriages in South India

  • Lakshmi Rao
  • Kanakavalli Murthy
  • Arvind Babu
  • Padmalatha Venkata
  • Mamata Deenadayal
  • Lalji Singh
Original Article


The aim of the present study was to investigate the contribution of chromosomal abnormalities and the frequency of a particular type of aberration in couples of South Indian origin with recurrent miscarriages. A total of 160 couples with recurrent miscarriages were analyzed using Giemsa-Trypsin-Giemsa (GTG) banding and Fluorescence in situ hybridization (FISH) wherever necessary. Chromosomal abnormalities were detected in 18 individuals representing 11.25% of the samples analyzed. Present study describes majority of the cases with chromosome inversions found to be common among the referred couples. Among the abnormal karyotypes, we report for the first time an unique case of chromosome insertion in a woman with the karyotype 46,XX,ins(12;6)(q24.2;q23q25) associated with recurrent miscarriages. The overall incidence of abnormalities and the predominance of chromosome inversions indicates to physicians that routine chromosome analysis of infertile couples of South Indian origin should be essentially considered before the planning of Intra Cytoplasmic Sperm Injection (ICSI), and also the priorities for cytogenetic screening in individual cases should be established.


Cytogenetics Chromosomal inversions FISH analysis Recurrent miscarriages 



The authors are thankful to Ms DV Jayanthi of Infertility Institute and Research Centre for her help in patient recruitment.


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Copyright information

© Springer-Verlag 2005

Authors and Affiliations

  • Lakshmi Rao
    • 1
  • Kanakavalli Murthy
    • 1
  • Arvind Babu
    • 1
  • Padmalatha Venkata
    • 1
  • Mamata Deenadayal
    • 2
  • Lalji Singh
    • 1
  1. 1.Centre for Cellular and Molecular BiologyHyderabadIndia
  2. 2.Infertility Institute and Research CentreSecunderabadIndia

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