Abstract
Aim: The regular Papanicolaou (Pap) smear is the cornerstone of women’s preventive healthcare. The introduction of the regular Pap smear as a screening tool for cervical cancer has markedly decreased the number of deaths from cervical cancer. During the past decade, however, the rate of death from cervical cancer has remained relatively static. This screening method is known to have a high percentage of false negative results. To improve the detection of cervical lesions using the Pap smear in screening, a number of adjunct procedures have been developed. The purpose of this study is to evaluate the utility of a magnified chemoluminescent screening examination (Colposcopy) combined with the Pap smear in detecting cervical abnormalities. Methods: We investigated a cohort of 58 subjects who have been forwarded for colposcopic evaluation due to referral cytology suggestive of persistent inflammatory process not otherwise specified, and cervical intraepithelial or invasive neoplasia, in Chania Colposcopic clinic. Results: The higher the lesion detected by cytology, the more severe the corresponding colposcopic impression viewed. Conclusion: The data presented here are in harmony with previous reports and share our experience in a Regional Community Hospital Colposcopy Clinic. An integrated cytology–colposcopy program facilitates the assessment and identification of women harboring cervical pathological conditions.
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Hinselmann H (1927) Zur Kenntnis der pracancerosen veranderungen der portio. Zentralbl Gynaecol 51:901
Hinselmann H (1933) Einfuhrung in die kolposkopic. Hartung, Hamburg
Stalf A, Mattingly R (1973) Colposcopic diagnosis of cervical neoplasia. Obstet Gynecol 41:168–176
Donohue L, Meriwether W (1972) Colposcopy as a diagnisis tool in the investigation of cervical neoplasias. Am J Obstet Gynecol 113:107–110
Townsend D, Ostergard D, Mishell D, Hirose F (1970) Abnormal Papanicolaou smears: evaluation by colposcopy, biopsies, and endocervical curettage. Am J Obstet Gynecol 108:429–434
Benedet JL, Boyes DA, Nicols TM, Millner A (1976) Colposcopic evaluation of patients with abnormal cervical cytology. Br J Obstet Gynaecol 83:177–182
Ortiz R, Newton M, Langois P (1969) Colposcopic biopsy in the diagnosis of carcinoma of the cervix. Obstet Gynecol 34:303–306
Ahlgren M, Ingemarsson I, Lindberg L, Nodqvist M, Nodqvist S (1975) Conization as treatment of carcinoma in situ of the uterine cervix. Obstet Gynecol 46:135–140
Burghardt E, Holtzer E (1980) Treatment of carcinoma in situ: evaluation of 1609 cases. Obtet Gynecol 55:539–545
Claman A, Lee N (1974) Factors that relate to complications of cone. Am J Obstet Gynecol 120:124–128
Bjerre B, Eliasson G, Linell F, Soderberg H, Sjoberg N (1976) Conization as only treatment of carcinoma in situ of the uterine cervix. Am J Obstet Gynecol 125:143–152
Bigrigg MA, Colding BW, Pearson P, Read MD, Swingler GR (1990) Colposcopic diagnosis and treatment of cervical dysplasia at a single clinic visit. Lancet 336:229–231
Keijser K, Kenemans P, van der Zanden H, Schijf C, Vooijs P, Rolland R (1992) Diathermy loops excision in the management of cervical intraepithelial neoplasia: diagnosis and treatment in one procedure. Am J Obstet Gynecol 166:1281–1287
Holschneider C, Ghosh K, Montz FJ (1999) See-and-treat in the management of high-grade squamous intraepithelial lesions of the cervix: a resource utilization analysis. Obstet Gynecol 94:377–385
Colleman DV, Evans DMD (1999) Biopsy pathology and cytology of the cervix, 2nd edn. Chapman and Hall Medical, London
Giuntoli R, Atkinson B, Ernst C, Rubin M, Egan V (1987) Atkinsons correlative atlas of colposcopy, cytology and histopathology, 1st edn. Lippincott, Philadelphia
Benedet JL, Anderson GH (1987) The accuracy of colposcopy in the diagnosis of preclinical invasive squamous carcinoma of the cervix. Colpo Gynecol Laser Surg 3:129–134
Wright TC, Cox JT, Massad LS, Twiggs LB, Wilkinson EJ (2002) 2001 Consensus guidelines for the management of women with cervical cytological abnormalities. JAMA 287:2120–2129
Conreras-Melendez L, Herbert A, Millward GR, Moore IE, Masson GM, Camillieri AP et al (1992) Assessment of the accuracy of cytology in women referred for colposcopy and biopsy: the results of a 1-year audit. Cytopathology 3:267–274
Kierkegaard O, Byrjalsen C, Fransden K, Frydenberg M (1994) Diagnostic accuracy of cytology and colposcopy in cervical squamous intraepithelial lesions. Acta Obstet Gynecol Scand 73:648–651
Mitchel MF (1994) The accuracy of colposcopy. Clin Consult Obstet Gynecol 6:70–73
Massad LS, Collins YC, Cejtin HE (1999) The accuracy of colposcopic impression among women undergoing directed biopsy. J Low Gen Tr Dis 3:57–58
Ley C, Bauer HM, Reingold A et al (1991) Determinants of genital HPV infection in young women. J Natl Cancer Inst 3:997–1000
Kiviat NB, Koutsky LA, Paavonen JA et al (1989) Prevalence of genital papillomavirus infection among women attending a college student health clinic or a sexually transmitted disease clinic. J Infect Dis 159:293–301
Zur Hausen H (1994) Molecular pathogenesis of cancer of the cervix and its causation by specific human papillomavirus types. Curr Top Microbiol Immunol 186:131–156
Lorincz AT, Reid R, Jenson AB et al (1992) Human papillomavirus infection of the cervix: relative risk association of 15 common anogenital types. Obstet Gynecol 79:328–337
United States Department of Health and Human Services (1989) Improving the quality of clinician Pap smear technique and management, client Pap smear education and evaluation of Pap smear laboratory testing: a resource guide for Title X family planning projects. Washington, DC, September 1989
Boring CC, Squires TS (1994) Tong T cancer statistics. CA Cancer J Clin 44:7–26
Nelson JH, Averette HE, Richart RM (1989) Cervical intraepithelial neoplasia (dysplasia and carcinoma in situ) and early invasive cervical carcinoma. CA Cancer J Clin 39:157–178
Larsen NS (1994) Invasive cervical cancer rate rising in young white females. Primary Care Cancer 14:15–17
Fruchter R, Boyce J, Hunt M (1980) Missed opportunities for early diagnosis of cancer of the cervix. Am J Pub Health 70:418–420
Paskett ED, Phillips KC, Miller ME (1995) Improving compliance among women with abnormal Papanicolaou smears. Obstet Gynecol 86:353–359
Apgar BS, Cox JT (1996) Differentiating normal and abnormal findings of the vulva. Am Fam Physician 53:1171–1180
Townsend GE (1984) Colposcopy: how to examine the vulva and vagina. Contemp Obstet Gynecol 23:161–173
Pfenninger JL (1989) Androscopy: a technique for examining men for condyloma. J Fam Practice 29:286–288
Ferenczy A, Hilgarth M, Jenny J et al (1988) The place of colposcopy and related systems in gynecologic practice and research [Editorial]. J Reprod Med 33:737–738
Cristoforoni PM, Gerbaldo D, Perino A et al (1995) Computed colposcopy: results of a pilot study and analysis of its clinical relevance. Obstet Gynecol 85:1011–1016
Sadan O, Schejter E, Ginath S et al (2004) Premalignant lesions of the uterine cervix in a large cohort of Jewish women. Arch Gynecol Obstet 269:188–191
Takacs P, Chakhtoura N, De Santis T (2004) Video colposcopy improves adherence to follow up compared to regular colposcopy: a randomized trial. Arch Gynecol Obstet 270:182–184
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Tamiolakis, D., Kalloniatou, M., Lambropoulou, M. et al. Contribution of combined colposcopy and cytology in cervical pathology. Arch Gynecol Obstet 273, 39–42 (2005). https://doi.org/10.1007/s00404-005-0018-x
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DOI: https://doi.org/10.1007/s00404-005-0018-x