Adenocarcinoma in situ coexisting with carcinoma in situ of the cervix during pregnancy
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We report a pregnant patient with adenocarcinoma in situ (AIS) coexisting with carcinoma in situ (CIS) of the cervix diagnosed by conization at 16 weeks' gestation. Apoptotic activity was higher in the CIS lesion than in the AIS lesion in the cone biopsy specimen. Postpartum evaluation confirmed the disappearance of CIS lesion with positive cone margins, however, multifocal AIS with negative cone margins was found.
Clinical course and biological features of AIS associated with pregnancy may be different from those of CIS.