Archives of Dermatological Research

, Volume 290, Issue 9, pp 477–482 | Cite as

IL-10 inhibits ICAM-1 expression on human Langerhans cells but not on keratinocytes, dermal endothelial cells or fibroblasts

  • R. Chatelain
  • Andreas Wollenberg
  • Corina Martin
  • Andrea Panhans-Gross
  • Thomas Bieber
  • Klaus Degitz
  • Marc Heckmann
Original paper

Abstract Intercellular adhesion molecule-1 (ICAM-1) is regularly expressed or inducible on all major cutaneous cell populations including Langerhans cells, keratinocytes, endothelial cells and dermal fibroblasts. ICAM-1 is induced in the skin under inflammatory conditions and plays an important role in the activation of T cells. Interleukin-10 (IL-10) is a pluripotent immunosuppressive cytokine that inhibits proliferation of T cells via inhibition of antigen-presenting cells including Langerhans cells. We demonstrates that IL-10 inhibits baseline and also cytokine-stimulated ICAM-1 expression on human Langerhans cells, which has previously been shown in the murine system. No effect of IL-10 was seen on human dermal vascular endothelial cells, which like Langerhans cells are also able to present antigen. Additionally, no inhibitory effect of IL-10 was observed on the ICAM-1 expression of keratinocytes and dermal fibroblasts. As IL-10 only weakly suppresses MCH II on human Langerhans cells, inhibition of ICAM-1 and other accessory molecules by IL-10 seems to be an important mechanism inhibiting the antigen-presenting function of human Langerhans cells.

Key words ICAM-1 Interleukin-10 Cytokines Langerhans cells Human skin 

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Copyright information

© Springer-Verlag Berlin Heidelberg 1998

Authors and Affiliations

  • R. Chatelain
    • 1
  • Andreas Wollenberg
    • 1
  • Corina Martin
    • 1
  • Andrea Panhans-Gross
    • 2
  • Thomas Bieber
    • 2
  • Klaus Degitz
    • 1
  • Marc Heckmann
    • 1
  1. 1.Department of Dermatology, Ludwig-Maximilians-University, Frauenlobstrasse 9–11, Munich, Germany Fax +49 89 5160 4664DE
  2. 2.Department of Dermatology, Friedrich-Wilhelms-University, Sigmund Freud Strasse 25, 53105 Bonn, GermanyDE

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