Archives of Dermatological Research

, Volume 289, Issue 12, pp 709–711

Immunosuppression by ultraviolet B rays via eyes in mice

  • K. Hiramoto
  • Yukiko Mashita
  • Tomonori Katada
  • Hiroaki Konishi
  • Mariko Sugiura
  • Ritsuko Hayakawa
Short communication

Abstract Irradiation by ultraviolet B (UV-B; 280–320 nm) initiates suppression of contact hypersensitivity. Immunosuppression was induced in C57BL/6N Crj mice by exposure of the dorsal skin or the eyes to a 10 kJ/m2 dose of UV-B radiation from 20SE sunlamps, followed by sensitization with 0.5% fluorescein isothiocyanate (FITC). The degree of immunosuppression induced by UV-B eye irradiation was equal to that induced by UV-B skin irradiation. When mice were irradiated with UV-B into the eyes after the optic nerve had been cut, systemic immunosuppression was not induced.

Key words Ultraviolet B Immunosuppression Contact hypersensitivity Eye Nervus opticus Skin 

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Copyright information

© Springer-Verlag Berlin Heidelberg 1997

Authors and Affiliations

  • K. Hiramoto
    • 1
  • Yukiko Mashita
    • 1
  • Tomonori Katada
    • 1
  • Hiroaki Konishi
    • 1
  • Mariko Sugiura
    • 2
  • Ritsuko Hayakawa
    • 2
  1. 1.Research Institute, Nippon Menard Cosmetic Co. Ltd., 2-7 Torimi-cho, Nishi-ku, Nagoya 451, Japan Tel. +81-52-531-6269; Fax +81-52-531-6277JP
  2. 2.Department of Dermatology, Nagoya University Branch Hospital, 1-1-20 Daikominami, Higashi-ku, Nagoya 453, JapanJP

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