Archives of Dermatological Research

, Volume 289, Issue 1, pp 1–8 | Cite as

Cytokines and their effects on maturation, differentiation and migration of dendritic cells

  • H. Jonuleit
  • Jürgen Knop
  • Alexander H. Enk

Abstract

In this review the role of cytokines in the maturation and migration of phenotypically and functionally diverse dendritic cell (DC) subpopulations is discussed and their role in the progress of differentiation from bone marrow progenitors to lymphoid DC is described. GM-CSF is the most important cytokine for the development of functional DC and acts in concert with a varying mixture of other cytokines such as IL-4, IL-1 and TNF-α to direct the development of individual DC subpopulations.

Key words Dendritic cell Langerhans cell Cytokines Dendritic cell differentiation 

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Copyright information

© Springer-Verlag Berlin Heidelberg 1996

Authors and Affiliations

  • H. Jonuleit
    • 1
  • Jürgen Knop
    • 1
  • Alexander H. Enk
    • 1
  1. 1.Department of Dermatology, University of Mainz, Langenbeckstr. 1, D-55131 Mainz, Germany Tel. 49-6131-173541; Fax 49-6131-176614DE

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