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Archives of Dermatological Research

, Volume 292, Issue 8, pp 412–417 | Cite as

Water content and thickness of the stratum corneum contribute to skin surface morphology

  • Junko Sato
  • Motohiro Yanai
  • Tetsuji Hirao
  • M. Denda
Original paper

Abstract Skin surface morphology has long been recognized as reflecting skin pathology. In the present study, we evaluated skin surface morphology using hairless mice under contrasting conditions of humidity. The skin surface microrelief was recorded with opaque quick-drying silicone rubber, and examined under a microscope. A binary image was produced by density slicing. Within 3 days of exposure to dry conditions, skin roughness was significantly increased. The skin roughness was partially mitigated by topical application of an aqueous solution of glycerol or hydration by immersion in water. A significant correlation between skin roughness and stratum corneum thickness was also observed. These results suggest that skin surface morphology is associated with both water content and thickness of the stratum corneum.

Key words Roughness Replica Humidity Dry skin Environment 

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Copyright information

© Springer-Verlag Berlin Heidelberg 2000

Authors and Affiliations

  • Junko Sato
    • 1
  • Motohiro Yanai
    • 1
  • Tetsuji Hirao
    • 1
  • M. Denda
    • 1
  1. 1.Skin Biology Research Laboratories, Shiseido Research Center, 2-12-1 Fukuura, Kanazawa-ku, Yokohama 236-8643, Japan e-mail: mitsuhiro.denda@to.shiseido.co.jp, Tel.: +81-45-7887268, Fax: +81-45-7887277JP

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