Archives of Dermatological Research

, Volume 311, Issue 4, pp 299–308 | Cite as

Malondialdehyde and advanced oxidation protein products are not increased in psoriasis: a controlled study

  • I. M. Skoie
  • I. Dalen
  • R. OmdalEmail author
  • G. Jonsson
Original Paper


This study investigated oxidative stress in patients with psoriasis of low and medium disease activity. We measured advanced oxidation protein products (AOPP) and malondialdehyde (MDA) in plasma using UV-spectrophotometry and high performance liquid chromatography connected to a fluorescence detector in 84 patients and 84 matched healthy subjects. AOPP is a marker of protein oxidation due to inflammation, whereas MDA is a hydroxyl radical initiated lipid peroxidation product. Clinico-demographic variables including age, gender, disease severity, and fatigue were assessed in relation to AOPP and MDA. Disease severity was evaluated with the Psoriasis Area and Severity Index and the Dermatology Life Quality Index. Median (interquartile range, IQR) AOPP concentrations were 66 µmol/l (IQR 54–102) in patients and 69 µmol/l (IQR 55–87) in healthy subjects (P = 0.75). Median plasma MDA concentrations were significantly lower in patients than in healthy subjects (0.68 µM, IQR 0.54–0.85 vs. 0.76 µM, IQR 0.60–0.97; P = 0.03). Plasma levels of AOPP and MDA did not indicate oxidative stress in patients with mild psoriasis. Higher AOPP concentrations were associated with male gender, high body mass index, and high hemoglobin values. Elevated MDA concentrations were associated with advanced age and male gender. No associations with disease severity were detected. Although, the two selected biomarkers do not provide a complete measure of oxidative damage, our study demonstrates that a number of physiological and methodological factors influence the levels of MDA and AOPP. Such methodological issues are important to consider when interpreting results using these biomarkers in patients with psoriasis.


Oxidative stress Advanced oxidation protein products AOPP Malondialdehyde MDA Psoriasis 



Advanced oxidation protein products




Reactive oxygen species


Interquartile range


Psoriasis area and severity index


Quality of life


Dermatology life quality index


Fatigue visual analog scale


The depression subscale of the Hospital Anxiety and Depression Scale


Thiobarbituric acid reactive substances


High-performance liquid chromatography connected to a fluorescence detector



Inger Marie Skoie received support as a doctoral research fellow from the Western Norway Regional Health Authority (WNRA, “Helse Vest”), Grant number (912015).

Compliance with ethical standards

Conflict of interest

The authors report no conflicts of interest.

Ethical approval

This study was approved by the Regional Committee for Medical Research Ethics in Norway (REK vest 2010/1455). All participants provided written informed consent, and the study was conducted in accordance with the latest revision of the Helsinki Declaration.

Supplementary material

403_2019_1903_MOESM1_ESM.pdf (82 kb)
Supplementary material 1 (PDF 81 KB)
403_2019_1903_MOESM2_ESM.pdf (96 kb)
Supplementary material 2 (PDF 96 KB)


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Copyright information

© Springer-Verlag GmbH Germany, part of Springer Nature 2019

Authors and Affiliations

  1. 1.Department of DermatologyStavanger University HospitalStavangerNorway
  2. 2.Section of Biostatistics, Research DepartmentStavanger University HospitalStavangerNorway
  3. 3.Clinical Immunology Unit, Department of Internal MedicineStavanger University HospitalStavangerNorway
  4. 4.Department of Clinical Science, Faculty of MedicineUniversity of BergenBergenNorway
  5. 5.Department of Medical BiochemistryStavanger University HospitalStavangerNorway

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