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Topically used herbal products for the treatment of hair loss: preclinical and clinical studies

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Abstract

Currently available conventional therapies of hair loss using synthetic drugs are still imperfect and have a number of limitations. Their effectiveness as well as the safety of their use is often questioned. It has led to an increased interest in alternative treatments with fewer side-effects such as formulations containing herbs and/or their active constituents. For this purpose several electronic databases and hand-searched references were used to summarize current knowledge regarding topically used herbal products for the treatment of hair loss acquired on the basis of preclinical and clinical studies. Moreover, mechanism of their action, follicular penetration and possible adverse effect of herbal products will be also described.

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References

  1. Aberer W (2008) Contact allergy and medicinal herbs. J Dtsch Dermatol Ges 6:15–24

    Article  PubMed  Google Scholar 

  2. Adhirajan N, Ravi Kumar T, Shanmugasundaram N, Babu M (2003) In vivo and in vitro evaluation of hair growth potential of Hibiscus rosa-sinensis Linn. J Ethnopharmacol 88:235–239

    Article  CAS  PubMed  Google Scholar 

  3. Amin J, Purba SEL, Anwar E, Djajadisastra J (2014) Green tea (Camellia sinensis L.) Ethanolic extracts as hair tonic in nutraceutical: physical stability, hair growth activity on rats, and safety test. Int J Pharm Pharm Sci 6:94–99

    Google Scholar 

  4. Anjum F, Bukhari SA, Shahid M, Bokhari TH, Talpur MM (2013) Exploration of nutraceutical potential of herbal oil formulated from parasitic plant. Afr J Tradit Complement Altern Med 11:78–86

    PubMed  PubMed Central  Google Scholar 

  5. Asif M (2012) A brief study of toxic effects of some medicinal herbs on kidney. Adv Biomed Res 1:44

    Article  PubMed  PubMed Central  Google Scholar 

  6. Asili J, Mosallaei N, Shaterzadeh A, Malaekeh-Nikouei B (2012) Preparation and characterization of liposomes containing methanol extract of aerial parts of Platycladus orientalis (L.) Franco. Avicenna J Phytomed 2:17–23

    Google Scholar 

  7. Banerjee PS, Sharma M, Nema RK (2009) Preparation, evaluation and hair growth stimulating activity of herbal hair oil. J Chem Pharm Res 1:261–267

    Google Scholar 

  8. Bazzano GS, Terezakis N, Galen W (1986) Topical tretinoin for hair growth promotion. J Am Acad Dermatol 15:880–883

    Article  CAS  PubMed  Google Scholar 

  9. Bedi MK, Shenefelt PD (2002) Herbal therapy in dermatology. Arch Dermatol 138:232–242

    Article  PubMed  Google Scholar 

  10. Begum S, Gu LJ, Lee MR, Li Z, Li JJ, Hossain MJ, Wang YB, Sung CK (2015) In vivo hair growth-stimulating effect of medicinal plant extract on BALB/c nude mice. Pharm Biol 53:1098–1103

    Article  PubMed  Google Scholar 

  11. Begum S, Lee MR, Gu LJ, Hossain J, Sung CK (2015) Exogenous stimulation with Eclipta alba promotes hair matrix keratinocyte proliferation and downregulates TGF-β1 expression in nude mice. Int J Mol Med 35:496–502

    Article  PubMed  Google Scholar 

  12. Bilsland D, Strong A (1990) Allergic contact dermatitis from the essential oil of French marigold (Tagetes Patula) in an aromatherapist. Contact Dermat 23:55–56

    Article  CAS  Google Scholar 

  13. Birch MP, Lalla SC, Messenger AG (2002) Female pattern hair loss. Clin Exp Dermatol 27:383–388

    Article  CAS  PubMed  Google Scholar 

  14. Blumeyer A, Tosti A, Messenger A, Reygagne P, Del Marmol V, Spuls PI, Trakatelli M, Finner A, Kiesewetter F, Trüeb R, Rzany B, Blume-Peytavi U (2011) Evidence-based (S3) guideline for the treatment of androgenetic alopecia in women and in men. J Dtsch Dermatol Ges 9:1–57

    Article  Google Scholar 

  15. Bode AM, Dong Z (2015) Toxic phytochemicals and their potential risks for human cancer. Cancer Prev Res 8:1–8

    Article  CAS  Google Scholar 

  16. Builders PF, Iwu IW, Mbah CC, Iwu IW, Builders MI, Audu MM (2014) Moringa oleifera ethosomes a potential hair growth activator: effect on rats. J Pharm Biomed Sci 04:611–618

    Google Scholar 

  17. Bunchorntavakul C, Reddy KR (2013) Review article: herbal and dietary supplement hepatotoxicity. Aliment Pharmacol Ther 37:3–17

    Article  CAS  PubMed  Google Scholar 

  18. Bureau JP, Ginouves P, Guilbaud J, Roux ME (2003) Essential oils and low-intensity electromagnetic pulses in the treatment of androgen-dependent alopecia. Adv Ther 20:220–229

    Article  CAS  PubMed  Google Scholar 

  19. Cárdenas A, Restrepo JC, Sierra F, Correa G (2006) Acute hepatitis due to shen-min: a herbal product derived from Polygonum multiflorum. J Clin Gastroenterol 40:629–632

    Article  PubMed  Google Scholar 

  20. Charuwichitratana S, Wattanakrai P, Tanrattanakorn S (2000) Randomized double-blind placebo-controlled trial in the treatment of alopecia areata with 0.25% desoximetasone cream. Arch Dermatol 136:1276–1277

    Article  CAS  PubMed  Google Scholar 

  21. Chaturvedi M, Kumar M, Sinhal A, Saifi A (2011) Recent development in novel drug delivery systems of herbal drugs. Int J Green Pharm 5:87–94

    Article  Google Scholar 

  22. Cheah YH, Nordin FJ, Abdullah NR, Ismail Z (2013) Effects of a local commercial herbal cleanser on hair growth in Wistar rats. J Med Plants Res 7:2906–2913

    Google Scholar 

  23. Cheung TP, Xue C, Leung K, Chan K, Li CG (2006) Aristolochic acids detected in some raw Chinese medicinal herbs and manufactured herbal products—a consequence of inappropriate nomenclature and imprecise labelling? Clin Toxicol 44:371–378

    Article  CAS  Google Scholar 

  24. Chittur S, Parr B, Marcovici G (2011) Inhibition of inflammatory gene expression in keratinocytes using a composition containing carnitine, thioctic acid and saw palmetto extract. Evid Based Complement Altern Med 2011:985345

    Article  Google Scholar 

  25. Choi EY, Park SN, Park SU, Choi S, Ro BI, Chung MH (2003) Promoting effect of a mixture of 8 herbal extracts (SPELA 707) on hair growth. Korean J Physiol Pharmacol 7:91–96

    Google Scholar 

  26. Choi JS, Jeon MH, Moon WS, Moon JN, Cheon EJ, Kim JW, Jung SK, Ji YH, Son SW, Kim MR (2014) In vivo hair growth-promoting effect of rice bran extract prepared by supercritical carbon dioxide fluid. Biol Pharm Bull 37:44–53

    Article  CAS  PubMed  Google Scholar 

  27. Choi JS, Jung SK, Jeon MH, Moon JN, Moon WS, Ji YH, Choi IS, Wook SS (2013) Effects of Lycopersicon esculentum extract on hair growth and alopecia prevention. J Cosmet Sci 64:429–443

    PubMed  Google Scholar 

  28. Colombe L, Vindrios A, Michelet JF, Bernard BA (2007) Prostaglandin metabolism in human hair follicle. Exp Dermatol 16:762–769

    Article  CAS  PubMed  Google Scholar 

  29. Danilenko DM, Ring BD, Yanagihara D, Benson W, Wiemann B, Starnes CO, Pierce GF (1995) Keratinocyte growth factor is an important endogenous mediator of hair follicle growth, development, and differentiation. Normalization of the nu/nu follicular differentiation defect and amelioration of chemotherapy-induced alopecia. Am J Pathol 147:145–154

    CAS  PubMed  PubMed Central  Google Scholar 

  30. de Groot AC, Weyland JW (1992) Systemic contact dermatitis from tea tree oil. Contact Dermat 27:279–280

    Article  Google Scholar 

  31. De Smet PA (2004) Health risks of herbal remedies: an update. Clin Pharmacol Ther 76:1–17

    Article  PubMed  Google Scholar 

  32. Dhanotia R, Chauhan NS, Saraf DK, Dixit VK (2011) Effect of Citrullus colocynthis Schrad fruits on testosterone-induced alopecia. Nat Prod Res 25:1432–1443

    Article  CAS  PubMed  Google Scholar 

  33. Ding Z, Wu M, Guo Q, Yang X, Zhang B (2013) Encapsulation of a flavonoid-rich Allium cepa L. var. agrogatum don extract in β-cyclodextrin for transdermal drug delivery. J Agric Food Chem 61:4914–4920

    Article  CAS  PubMed  Google Scholar 

  34. du Cros DL (1993) Fibroblast growth factor and epidermal growth factor in hair development. J Invest Dermatol 101:106–113

    Article  Google Scholar 

  35. Dwivedi S, Aggarwal A, Sharma V (2011) Cardiotoxicity from ‘safe’ herbomineral formulations. Trop Dr 41:113–115

    Google Scholar 

  36. Ernst E (2000) Adverse effects of herbal drugs in dermatology. Br J Dermatol 143:923–929

    Article  CAS  PubMed  Google Scholar 

  37. Fischer TW, Hipler UC, Elsner P (2007) Effect of caffeine and testosterone on the proliferation of human hair follicles in vitro. Int J Dermatol 46:27–35

    Article  PubMed  Google Scholar 

  38. Fong P, Tong HH, Ng KH, Lao CK, Chong CI, Chao CM (2015) In silico prediction of prostaglandin D2 synthase inhibitors from herbal constituents for the treatment of hair loss. J Ethnopharmacol 175:470–480

    Article  CAS  PubMed  Google Scholar 

  39. Giordano-Labadie F, Schwarze HP, Bazex J (2000) Allergic contact dermatitis from camomile used in phytotherapy. Contact Dermat 42:247

    CAS  Google Scholar 

  40. Gnann LA, Castro RF, Azzalis LA, Feder D, Perazzo FF, Pereira EC et al (2013) Hematological and hepatic effects of vascular epidermal growth factor (VEGF) used to stimulate hair growth in an animal model. BMC Dermatol 13:15

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  41. Gottumukkala VR, Annamalai T, Mukhopadhyay T (2011) Phytochemical investigation and hair growth studies on the rhizomes of Nardostachys jatamansi DC. Pharmacogn Mag 7:146–150

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  42. Greco V, Chen T, Rendl M, Schober M, Pasoli HA, Stokes N et al (2009) A two-step mechanism for stem cell activation during hair regeneration. Cell Stem Cell 4:155–169

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  43. Greenberg JH, Katz M (1996) Treatment of androgenetic alopecia with a 7.5% herbal preparation. J Dermatol Treat 7:159–162

    Article  Google Scholar 

  44. Gupta PK, Chauhan NS, Pathak A (2013) Effect of Trigonella foenum-graecum Linn. (seeds) and Butea monosperma Lam. (flowers) on chemotherapy-induced alopecia. Spatula DD 3:121–125

    Article  Google Scholar 

  45. Hajheydari Z, Jamshidi M, Akbari J, Mohammadpour R (2007) Combination of topical garlic gel and betamethasone valerate cream in the treatment of localized alopecia areata: a double-blind randomized controlled study. Indian J Dermatol Venereol Leprol 73:29–32

    Article  PubMed  Google Scholar 

  46. Hansen LA, Alexander N, Hogan ME, Sundberg JP, Dlugosz A, Threadgill DW et al (1997) Genetically null mice reveal a central role for epidermal growth factor receptor in the differentiation of the hair follicle and normal hair development. Am J Pathol 150:1959–1975

    CAS  PubMed  PubMed Central  Google Scholar 

  47. Harada N, Okajima K, Narimatsu N, Kurihara H, Nakagata N (2008) Effect of topical application of raspberry ketone on dermal production of insulin-like growth factor-I in mice and on hair growth and skin elasticity in humans. Growth Horm IGF Res 18:335–344

    Article  CAS  PubMed  Google Scholar 

  48. Hay IC, Jamieson M, Ormerod AD (1998) Randomized trial of aromatherapy successful treatment for alopecia areata. Arch Dermatol 134:1349–1352

    Article  CAS  PubMed  Google Scholar 

  49. Hébert JM, Rosenquist T, Götz J, Martin GR (1994) FGF5 as a regulator of the hair growth cycle: evidence from targeted and spontaneous mutations. Cell 78:1017–1025

    Article  PubMed  Google Scholar 

  50. Herman A, Herman AP (2013) Caffeine’s mechanisms of action and its cosmetic use. Skin Pharmacol Physiol 26:8–14

    Article  CAS  PubMed  Google Scholar 

  51. Herman A, Herman AP (2015) Essential oils and their constituents as skin penetration enhancer for transdermal drug delivery: a review. J Pharm Pharmacol 67:473–485

    Article  CAS  PubMed  Google Scholar 

  52. Herman A, Herman AP (2016) Mechanism of action of herbs and their active constituents used in hair loss treatment. Fitoterapia 114:18–25

    Article  CAS  PubMed  Google Scholar 

  53. Hiipakka RA, Zhang HZ, Dai W, Dai Q, Liao S (2002) Structure–activity relationships for inhibition of human 5α-reductases by polyphenols. Biochem Pharmacol 63:1165–1176

    Article  CAS  PubMed  Google Scholar 

  54. Hirata N, Tokunaga M, Naruto S, Iinuma M, Matsuda H (2007) Testosterone 5 alpha-reductase inhibitory active constituents of Piper nigrum leaf. Biol Pharm Bull 30:2402–2405

    Article  CAS  PubMed  Google Scholar 

  55. Huelsken J, Vogel R, Erdmann B, Cotsarelis G, Birchmeier W (2001) β-Catenin controls hair follicle morphogenesis and stem cell differentiation in the skin. Cell 105:533–545

    Article  CAS  PubMed  Google Scholar 

  56. Huh S, Lee J, Jung E, Kim SC, Kang JI, Lee J et al (2009) A cell-based system for screening hair growth-promoting agents. Arch Dermatol Res 301:381–385

    Article  CAS  PubMed  Google Scholar 

  57. Huxtable RJ (1992) The myth of beneficent nature: the risks of herbal preparations. Ann Intern Med 117:165–166

    Article  CAS  PubMed  Google Scholar 

  58. Hwang MK, Bode AM, Byun S, Song NR, Lee HJ, Lee KW, Dong Z (2010) Cocarcinogenic effect of capsaicin involves activation of EGFR signaling but not TRPV1. Cancer Res 70:6859–6869

    Article  CAS  PubMed  Google Scholar 

  59. Hwang SL, Kim JC (2008) In vivo hair growth promotion effects of cosmetic preparations containing hinokitiol-loaded poly (ϵ-caprolacton) nanocapsules. J Microencapsul 25:351–356

    Article  CAS  PubMed  Google Scholar 

  60. Ishida H, Inaoka Y, Shibatani JI, Fukushima M, Tsuji K (1999) Studies of the active substances in herbs used for hair treatment. II. Isolation of hair regrowth substances, acetosyringone and polyporusterone A and B, from Polyporus umbellatus fries. Biol Pharm Bull 22:1189–1192

    Article  CAS  PubMed  Google Scholar 

  61. Jaybhaye D, Varma S, Gagne N, Bonde V, Gite A, Bhosle D (2010) Effect of Tectona grandis Linn. seeds on hair growth activity of albino mice. Int J Ayurveda Res 1:211–215

    Article  PubMed  PubMed Central  Google Scholar 

  62. Jeong CG, Park MH, Seong JW, Lee HS, Park SK, Kim SY et al (2008) Immunohistochemical study on the hair growth promoting effect of Yonnyuniksoogobon-dan. J Korean Orient Med 29:77–89

    Google Scholar 

  63. Johne A, Brockmöller J, Bauer S, Maurer A, Langheinrich M, Roots I (1999) Pharmacokinetic interaction of digoxin with an herbal extract from St John’s wort (Hypericum perforatum). Clin Pharmacol Ther 66:338–345

    Article  CAS  PubMed  Google Scholar 

  64. Johne A, Schmider J, Brockmöller J, Stadelmann AM, Störmer E, Bauer S, Scholler G, Langheinrich M, Roots I (2002) Decreased plasma levels of amitriptyline and its metabolites on comedication with an extract from St. John’s wort (Hypericum perforatum). J Clin Psychopharmacol 22:46–54

    Article  CAS  PubMed  Google Scholar 

  65. Joshi BS, Kaul PN (2001) Alternative medicine: herbal drugs and their critical appraisal—part I. Prog Drug Res 56:1–76

    CAS  PubMed  Google Scholar 

  66. Junlatat J, Sripanidkulchai B (2014) Hair growth-promoting effect of Carthamus tinctorius floret extract. Phytother Res 28:1030–1036

    Article  PubMed  Google Scholar 

  67. Kamimura A, Takahashi T (2002) Procyanidin B-3, isolated from barley and identified as a hair-growth stimulant, has the potential to counteract inhibitory regulation by TGF-β1. Exp Dermatol 11:532–541

    Article  CAS  PubMed  Google Scholar 

  68. Kamimura A, Takahashi T, Watanabe Y (2000) Investigation of topical application of procyanidin B-2 from apple to identify its potential use as a hair growing agent. Phytomedicine 7:529–536

    Article  CAS  PubMed  Google Scholar 

  69. Kang JI, Kim EJ, Kim MK, Jeon YJ, Kang SM, Koh YS, Yoo ES, Kang HK (2013) The promoting effect of Ishige sinicola on hair growth. Mar Drugs 11:1783–1799

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  70. Kang JI, Kim SC, Hyun JH, Kang JH, Park DB, Lee YJ et al (2009) Promotion effect of Schisandra nigra on the growth of hair. Eur J Dermatol 19:119–125

    PubMed  Google Scholar 

  71. Karliova M, Treichel U, Malagò M, Frilling A, Gerken G, Broelsch CE (2000) Interaction of Hypericum perforatum (St. John’s wort) with cyclosporin A metabolism in a patient after liver transplantation. J Hepatol 33:853–855

    Article  CAS  PubMed  Google Scholar 

  72. Kaufman KD, Olsen EA, Whiting D, Savin R, DeVillez R, Bergfeld W, Price VH, Van Neste D, Roberts JL, Hordinsky M, Shapiro J, Binkowitz B, Gormley GJ (1998) Finasteride in the treatment of men with androgenetic alopecia. Finasteride Male Pattern Hair Loss Study Group. J Am Acad Dermatol 39:578–589

    Article  CAS  PubMed  Google Scholar 

  73. Kew J, Morris C, Aihie A, Fysh R, Jones S, Brooks D (1993) Arsenic and mercury intoxication due to Indian ethnic remedies. BMJ 306:506–507

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  74. Kim AR, Kim SN, Jung IK, Kim HH, Park YH, Park WS (2014) The inhibitory effect of Scutellaria baicalensis extract and its active compound, baicalin, on the translocation of the androgen receptor with implications for preventing androgenetic alopecia. Planta Med 80:153–158

    Article  CAS  PubMed  Google Scholar 

  75. Kim EJ, Choi JY, Park BC, Lee BH (2014) Platycarya strobilacea S. et Z. extract has a high antioxidant capacity and exhibits hair growth-promoting effects in male C57BL/6 mice. Prev Nutr Food Sci 19:136–144

    Article  PubMed  PubMed Central  Google Scholar 

  76. Kim JS, Kang BS, Park HJ, Kim DY, Hwang SY, Nam SY, Yun YW, Lee BJ (2009) Promoting effect of herbal extracts mixtures on hair regrowth in C3H/HeJ mice. J Biomed Res 10:99–108

    Google Scholar 

  77. Kim SC, Kang JI, Park DB, Lee YK, Hyun JW, Koh YS et al (2012) Promotion effect of acankoreoside J, a lupane-triterpene in Acanthopanax koreanum, on hair growth. Arch Pharm Res 35:1495–1503

    Article  CAS  PubMed  Google Scholar 

  78. Kumar N, Rungseevijitprapa W, Narkkhong NA, Suttajit M, Chaiyasut C (2012) 5α-reductase inhibition and hair growth promotion of some Thai plants traditionally used for hair treatment. J Ethnopharmacol 139:765–771

    Article  PubMed  Google Scholar 

  79. Kumar N, Singh S, Gupta R (2011) Hair growth activity of Trichosanthes dioica R. leaves. Res J Pharmacogn Phytochem 3:30–33

    Google Scholar 

  80. Kwon OS, Han JH, Yoo HG, Chung JH, Cho KH, Eun HC, Kim KH (2007) Human hair growth enhancement in vitro by green tea epigallocatechin-3-gallate (EGCG). Phytomedicine 14:551–555

    Article  CAS  PubMed  Google Scholar 

  81. Kwon TK, Kim JC (2010) Preparation and in vitro skin permeation of cubosomes containing hinokitiol. J Dispers Sci Technol 31:1004–1009

    Article  CAS  Google Scholar 

  82. Lademann J, Richter H, Schanzer S, Klenk A, Sterry W, Patzelt A (2010) Analysis of the penetration of a caffeine containing shampoo into the hair follicles by in vivo laser scanning microscopy. Laser Phys 20:551–556

    Article  CAS  Google Scholar 

  83. Lee EY, Choi EJ, Kim JA, Hwang YL, Kim CD, Lee MH et al (2016) Malva verticillata seed extracts upregulate the Wnt pathway in human dermal papilla cells. Int J Cosmet Sci 38:148–154

    Article  CAS  PubMed  Google Scholar 

  84. Lee GS, Hong EJ, Gwak KS, Park MJ, Choi KC, Choi IG et al (2010) The essential oils of Chamaecyparis obtusa promote hair growth through the induction of vascular endothelial growth factor gene. Fitoterapia 81:17–24

    Article  CAS  PubMed  Google Scholar 

  85. Leow YH (1997) Contact dermatitis due to topical traditional Chinese medication. Clin Dermatol 15:601–605

    Article  CAS  PubMed  Google Scholar 

  86. Li Y, Han M, Lin P, He Y, Yu J, Zhao R (2015) Hair growth promotion activity and its mechanism of Polygonum multiflorum. Evid Based Complement Altern Med. doi:10.1155/2015/517901

    Google Scholar 

  87. Libecco JF, Bergfeld WF (2001) Finasteride in the treatment of alopecia. Expert Opin Pharmacother 5:933–940

    Article  Google Scholar 

  88. Loing E, Lachance R, Ollier V, Hocquaux M (2013) A new strategy to modulate alopecia using a combination of two specific and unique ingredients. J Cosmet Sci 64:45–58

    CAS  PubMed  Google Scholar 

  89. MacDonald Hull SP, Wood ML, Hutchinson PE, Sladden M, Messenger AG (2003) Guidelines for the management of alopecia areata. Br J Dermatol 149:692–699

    Article  CAS  PubMed  Google Scholar 

  90. Manach C, Scalbert A, Morand C, Rémésy C, Jiménez L (2004) Polyphenols: food sources and bioavailability. Am J Clin Nutr 79:727–747

    CAS  PubMed  Google Scholar 

  91. Mancuso G, Balducci A, Casadio C, Farina P, Staffa M, Valenti L, Milani M (2003) Efficacy of betamethasone valerate foam formulation in comparison with betamethasone dipropionate lotion in the treatment of mild-to-moderate alopecia areata: a multicenter, prospective, randomized, controlled, investigator blinded trial. Int J Dermatol 42:572–575

    Article  CAS  PubMed  Google Scholar 

  92. Mathijssen RH, Verweij J, de Bruijn P, Loos WJ, Sparreboom A (2002) Effects of St. John’s wort on irinotecan metabolism. J Nat Cancer Inst 94:1247–1249

    Article  CAS  PubMed  Google Scholar 

  93. Matsuda H, Yamazaki M, Asanuma Y, Kubo M (2003) Promotion of hair growth by ginseng radix on cultured mouse vibrissal hair follicles. Phytother Res 17:797–800

    Article  CAS  PubMed  Google Scholar 

  94. Matsuda H, Yamazaki M, Matsuo K, Asanuma Y, Kubo M (2001) Anti-androgenic activity of Myricae Cortex. Isolation of active constituents from bark of Myrica rubra. Biol Pharm Bull 24:259–263

    Article  CAS  PubMed  Google Scholar 

  95. Matsuda H, Yamazaki M, Naruto S, Asanuma Y, Kubo M (2002) Anti-androgenic and hair growth promoting activities of Lygodii spora (spore of Lygodium japonicum) I. active constituents inhibiting testosterone 5 alpha-reductase. Biol Pharm Bull 25:622–626

    Article  CAS  PubMed  Google Scholar 

  96. McClellan JK, Markham A (1999) Finesteride. A review of its use in male pattern hair loss. Drugs 57:111–126

    Article  CAS  PubMed  Google Scholar 

  97. Meidan VM, Touitou E (2001) Treatments for androgenetic alopecia and alopecia areata: current options and future prospects. Drugs 61:53–69

    Article  CAS  PubMed  Google Scholar 

  98. Miao Y, Sun Y, Wang W, Du B, Xiao SE, Hu Y, Hu Z (2013) 6-Gingerol inhibits hair shaft growth in cultured human hair follicles and modulates hair growth in mice. PLoS One 8:e57226

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  99. Michie HJ, Jahoda CAB, Oliver RF, Johnson BE (1991) The DEBR rat: an animal model of human alopecia areata. Br J Dermatol 125:94–100

    Article  CAS  PubMed  Google Scholar 

  100. Murata K, Noguchi K, Kondo M, Onishi M, Watanabe N, Okamura K, Matsuda H (2013) Promotion of hair growth by Rosmarinus officinalis leaf extract. Phytother Res 27:212–217

    Article  PubMed  Google Scholar 

  101. Murata K, Noguchi K, Kondo M, Onishi M, Watanabe N, Okamura K, Matsuda H (2012) Inhibitory activities of Puerariae flos against testosterone 5α-reductase and its hair growth promotion activities. J Nat Med 66:158–165

    Article  CAS  PubMed  Google Scholar 

  102. Murata K, Takeshita F, Samukawa K, Tani T, Matsuda H (2012) Effects of Ginseng Rhizome and Ginsenoside Ro on testosterone 5α-reductase and hair re-growth in testosterone-treated mice. Phytother Res 26:48–53

    Article  CAS  PubMed  Google Scholar 

  103. Murkute AV, Sahu MS, Mali PY, Rangari VD (2010) Development and evaluation of formulations of microbial biotransformed extract of tobacco leaves for hair growth potential. Pharmacogn Res 2:300–303

    Article  Google Scholar 

  104. Nandeesh R, Kumar BSA, Lakshman K, Khan S, Swamy VBN, Bharathi T, Ganapathy S (2009) Evaluation of hair growth activity of Buxus wallichiana Baill extract in rats. Iran J Basic Med Sci 11:236–241

    Google Scholar 

  105. Neetu S, Dhanila V, Rakesh B, Anjali K, Ashish J, Sanjay J (2009) Development and evaluation of polyherbal formulations for hair growth activity. Pharmacogn J 1:165–170

    Google Scholar 

  106. Niggemann B, Grüber C (2003) Side-effects of complementary and alternative medicine. Allergy 58:707–716

    Article  CAS  PubMed  Google Scholar 

  107. Nortier JL, Martinez MC, Schmeiser HH, Arlt VM, Bieler CA, Petein M, Depierreux MF, De Pauw L, Abramowicz D, Vereerstraeten P, Vanherweghem JL (2000) Urothelial carcinoma associated with the use of a Chinese herb (Aristolochia fangchi). N Engl J Med 342:1686–1692

    Article  CAS  PubMed  Google Scholar 

  108. Oh JY, Park MA, Kim YC (2014) Peppermint oil promotes hair growth without toxic signs. Toxicol Res 30:297–304

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  109. Olsen EA, Dunlap FE, Funicella T, Koperski JA, Swinehart JM, Tschen EH, Trancik RJ (2001) A randomized clinical trial of 5% topical minoxidil versus 2% topical minoxidil and placebo in the treatment of androgenetic alopecia in men. J Am Acad Dermatol 47:377–385

    Article  Google Scholar 

  110. Ozeki M, Tabata Y (2002) Promoted growth of murine hair follicles through controlled release of basic fibroblast growth factor. Tissue Eng 8:359–366

    Article  CAS  PubMed  Google Scholar 

  111. Pamudji JS, Suciati T, Sukander EY, Fidriani I (2015) Microemulsion formulation of Aloe vera gel and Apium graveolens ethanol extract for hair growth promotion. Asian J Pharm Clin Res 8:319–323

    Google Scholar 

  112. Panahi Y, Taghizadeh M, Marzony ET, Sahebkar A (2014) Rosemary oil vs minoxidil 2% for the treatment of androgenetic alopecia: a randomized comparative trial. Skinmed 13:15–21

    Google Scholar 

  113. Pandit S, Chauhan NS, Dixit VK (2008) Effect of Cuscuta reflexa Roxb on androgen-induced alopecia. J Cosmet Dermatol 7:199–204

    Article  PubMed  Google Scholar 

  114. Panis B, Wong DR, Hooymans PM, De Smet PAM, Rosias PP (2005) Recurrent toxic hepatitis in a Caucasian girl related to the use of Shou-Wu-Pian, a Chinese herbal preparation. J Pediatr Gastroenterol Nutr 41:256–258

    Article  PubMed  Google Scholar 

  115. Park HJ, Zhang N, Park DK (2011) Topical application of Polygonum multiflorum extract induces hair growth of resting hair follicles through upregulating Shh and β-catenin expression in C57BL/6 mice. J Ethnopharmacol 135:369–375

    Article  PubMed  Google Scholar 

  116. Park KM, Kim DW, Lee SH (2015) Extract of Allium tuberosum Rottler ex Spreng promoted the hair growth through regulating the expression of IGF-1. Evid Based Complement Altern Med 2015:413538

    Google Scholar 

  117. Park PJ, Moon BS, Lee SH, Kim SN, Kim AR, Kim HJ, Park WS, Choi KY, Cho EG, Lee TR (2012) Hair growth promoting effect of Aconiti Ciliare Tuber extract mediated by the activation of Wnt/β-catenin signaling. Life Sci 91:935–943

    Article  CAS  PubMed  Google Scholar 

  118. Park SY, Kim TY, Shin SM, Park IS, Kim KB, Lee JH (2015) Effects of SM-215 on hair growth by hair follicle stimulation. Indian J Sci Technol 8:1–8

    Google Scholar 

  119. Park WS, Lee CH, Lee BG, Chang IS (2003) The extract of Thujae occidentalis semen inhibited 5α-reductase and androchronogenetic alopecia of B6CBAF1/j hybrid mouse. J Dermatol Sci 31:91–98

    Article  PubMed  Google Scholar 

  120. Pascher F, Kurtin S, Andrade R (1978) Assay of 0.2% fluocinolone acetonide cream for alopecia areata and totalis. Dermatologica 141:193–202

    Article  Google Scholar 

  121. Prager N, Bickett K, French N, Marcovici G (2002) A randomized, double-blind, placebo-controlled trial to determine the effectiveness of botanically derived inhibitors of 5-alpha-reductase in the treatment of androgenetic alopecia. J Altern Complement Med 8:143–152

    Article  PubMed  Google Scholar 

  122. Pumthong G, Asawanonda P, Varothai S, Jariyasethavong V, Triwongwaranat D, Suthipinittharm P, Ingkaninan K, Leelapornpisit P, Waranuch N (2012) Curcuma aeruginosa, a novel botanically derived 5α-reductase inhibitor in the treatment of male-pattern baldness: a multicenter, randomized, double-blind, placebo-controlled study. J Dermatol Treat 23:385–392

    Article  Google Scholar 

  123. Purwal L, Gupta SPBN, Pande SM (2008) Development and evaluation of herbal formulations for hair growth. J Chem 5:34–38

    Google Scholar 

  124. Rathi V, Rathi JC, Tamizharasi S (2009) Development and evaluation of polyherbal formulations for hair growth potential. Pharmacogn Res 1:234–237

    Google Scholar 

  125. Rho SS, Park SJ, Hwang SL, Lee MH, Kim CD, Lee IH, Chang SY, Rang MJ (2005) The hair growth promoting effect of Asiasari radix extract and its molecular regulation. J Dermatol Sci 38:89–97

    Article  PubMed  Google Scholar 

  126. Roy RK, Thakur M, Dixit VK (2008) Hair growth promoting activity of Eclipta alba in male albino rats. Arch Dermatol Res 300:357–364

    Article  CAS  PubMed  Google Scholar 

  127. Sahoo HB, Sagar R, Bhattamisra SK, Bhaiji A (2013) Preliminary study on the impact of methanolic extract of Elephantopus scaber Linn. on hair growth promoting effect in rats. Herba Pol 59:35–45

    Google Scholar 

  128. Sandhya S, Chandra SJ, Vino KR, Rao KNV, Banji D (2012) Preclinical studies of a novel polyherbal phyto–complex hair growth promoting cream. Asian Pac J Trop Biomed 2:S296–S304

    Article  Google Scholar 

  129. Saraf AS (2010) Applications of novel drug delivery system for herbal formulations. Fitoterapia 81:680–689

    Article  PubMed  CAS  Google Scholar 

  130. Schmid D, Belser E, Zülli F (2014) Stimulation of hair growth by enhancing the expression of FGF7 and noggin genes. Mibelle Group Biochemistry, Switzerland

  131. Schmoeckel C, Weissmann I, Plewig G, Braun-Falco O (1979) Treatment of alopecia areata by anthralin-induced dermatitis. Arch Dermatol 115:1254–1255

    Article  CAS  PubMed  Google Scholar 

  132. Semalty M, Semalty A, Geeta PJ, Rawat MSM (2010) In vivo hair growth activity of herbal formulations. Int J Pharmacol 6:53–57

    Article  Google Scholar 

  133. Semwal BC, Agrawal KK, Singh K, Tandon S, Sharma S (2011) Alopecia: switch to herbal medicine. J Pharm Res Opin 1:101–104

    Google Scholar 

  134. Seo SR, Kang G, Ha JW, Kim JC (2013) In vivo hair growth-promoting efficacies of herbal extracts and their cubosomal suspensions. J Ind Eng Chem 19:1331–1339

    Article  CAS  Google Scholar 

  135. Shao LX (2003) Effects of the extract from bergamot and boxthorn on the delay of skin aging and hair growth in mice. China J Chin Mater Med 28:766–769

    Google Scholar 

  136. Shapiro J, Price VH (1998) Hair regrowth: therapeutic agents. Dermatol Clin 16:341–356

    Article  CAS  PubMed  Google Scholar 

  137. Sharquie KE, Al-Obaidi HK (2002) Onion juice (Allium cepa L.), a new topical treatment for alopecia areata. J Dermatol 29:343–346

    Article  PubMed  Google Scholar 

  138. Shimizu K, Kondo R, Sakai K, Shoyama Y, Sato H, Ueno T (2000) Steroid 5α-reductase inhibitory activity and hair regrowth effects of an extract from Boehmeria nipononivea. Biosci Biotechnol Biochem 64:875–877

    Article  CAS  PubMed  Google Scholar 

  139. Shin HS, Park SY, Song HG, Hwang E, Lee DG, Yi TH (2015) The androgenic alopecia protective effects of forsythiaside A and the molecular regulation in a mouse model. Phytother Res 29:870–876

    Article  CAS  PubMed  Google Scholar 

  140. Sinclair R, Wewerinke M, Jolley D (2005) Treatment of female pattern hair loss with oral antiandrogens. Br J Dermatol 152:466–473

    Article  CAS  PubMed  Google Scholar 

  141. Singh RP, Parpani S, Narke R, Chavan R (2014) Phytosome: recent advance research for novel drug delivery system. Asian J Pharm Res Development 2:15–29

    Google Scholar 

  142. Smith P, Bullock JM, Booker BM, Haas CE, Berenson CS, Jusko WJ (2004) The influence of St. John’s wort on the pharmacokinetics and protein binding of imatinib mesylate. Pharmacother 24:1508–1514

    Article  CAS  Google Scholar 

  143. Spindler JR (1988) The safety of topical minoxidil solution in the treatment of pattern baldness: the results of a 27-center trial. Clin Dermatol 6:200–212

    Article  CAS  PubMed  Google Scholar 

  144. Stedman C (2002) Herbal hepatotoxicity. Semin Liver Dis 22:195–206

    Article  CAS  PubMed  Google Scholar 

  145. Sundberg JP, Boggess D, Montagutelli X, Hogan ME, King LE Jr (1995) C3H/HeJ mouse model for alopecia areata. J Invest Dermatol 104:16–17

    Article  Google Scholar 

  146. Suraja R, Rejithaa G, Sunilsona JAJ, Anandarajagopala K, Promwichita P (2009) In vivo hair growth activity of Prunus dulcis seeds in rats. Biol Med 1:34–38

    Google Scholar 

  147. Sutthanut K, Lu X, Jay M, Sripanidkulchai B (2009) Solid lipid nanoparticles for topical administration of Kaempferia parviflora extracts. J Biomed Nanotechnol 5:224–232

    Article  CAS  PubMed  Google Scholar 

  148. Takahashi T, Kamiya T, Yokoo Y (1998) Proanthocyanidins from grape seeds promote proliferation of mouse hair follicle cells in vitro and convert hair cycle in vivo. Acta Derm Venereol 78:428–432

    Article  CAS  PubMed  Google Scholar 

  149. Teichmann A, Heuschkel S, Jacobi U, Presse G, Neubert RH, Sterry W, Lademann J (2007) Comparison of stratum corneum penetration and localization of a lipophilic model drug applied in an o/w microemulsion and an amphiphilic cream. Eur J Pharm Biopharm 67:699–706

    Article  CAS  PubMed  Google Scholar 

  150. Teichmann A, Richter H, Knorr F, Antoniou C, Sterry W, Lademann J (2007) Investigation of the penetration and storage of a shampoo formulation containing caffeine into the hair follicles by in vivo laser scanning microscopy. Laser Phys Lett 4:464–468

    Article  CAS  Google Scholar 

  151. Thorat RM, Jadhav VM, Kadam VJ (2009) Development and evaluation of polyherbal formulations for hair growth-promoting activity. Int J Pharm Tech Res 1:1251–1254

    CAS  Google Scholar 

  152. Tosti A, Bellavista S, Iorizzo M (2006) Alopecia areata: a long term follow-up study of 191 patients. J Am Acad Dermatol 55:438–441

    Article  PubMed  Google Scholar 

  153. Tosti A, Iorizzo M, Botta GL, Milani M (2006) Efficacy and safety of a new clobetasol propionate 0.05% foam in alopecia areata: a randomized double blind placebo controlled trial. J Eur Acad Dermatol Venereol 20:1243–1247

    Article  PubMed  Google Scholar 

  154. Tosti A, Piraccini BM, Pazzaglia M, Vincenzi C (2003) Clobetasol propionate 0.05% under occlusion in the treatment of alopecia totalis/universalis. J Am Acad Dermatol 49:96–98

    Article  PubMed  Google Scholar 

  155. Tsujimoto H, Hara K, Tsukada Y, Huang CC, Kawashima Y, Arakaki M, Okayasu H, Mimura H, Miwa N (2007) Evaluation of the permeability of hair growing ingredient encapsulated PLGA nanospheres to hair follicles and their hair growing effects. Bioorg Med Chem Lett 17:4771–4777

    Article  CAS  PubMed  Google Scholar 

  156. Tsuruki T, Takahata K, Yoshikawa M (2005) Anti-alopecia mechanisms of soymetide-4, an immunostimulating peptide derived from soy β-conglycinin. Peptides 26:707–711

    Article  CAS  PubMed  Google Scholar 

  157. Upadhyay S, Dixit VK, Ghosh AK, Singh V (2012) Effect of petroleum ether and ethanol fractions of seeds of Abrus precatorius on androgenic alopecia. Rev Bras Farmacogn 22:359–363

    Article  Google Scholar 

  158. Upadhyay S, Ghosh AK, Singh V (2012) Hair growth promotant activity of petroleum ether root extract of Glycyrrhiza glabra L. (Fabaceae) in female rats. Trop J Pharm Res 11:753–758

    Google Scholar 

  159. Varothai S, Bergfeld WF (2014) Androgenetic alopecia: an evidence-based treatment update. Am J Clin Dermatol 15:217–230

    Article  PubMed  Google Scholar 

  160. Verhelst X, Burvenich P, Van Sassenbroeck D, Gabriel C, Lootens M, Baert D (2009) Acute hepatitis after treatment for hair loss with oral green tea extracts (Camellia sinensis). Acta Gastroenterol Belg 72:262–264

    CAS  PubMed  Google Scholar 

  161. Vestey JP, Savin JA (1986) A trial of 1% minoxidil used topically for severe alopecia areata. Acta Derm Venereol 66:179–180

    CAS  PubMed  Google Scholar 

  162. Wang XD, Li JL, Lu Y, Chen X, Huang M, Chowbay B, Zhou SF (2007) Rapid and simultaneous determination of nifedipine and dehydronifedipine in human plasma by liquid chromatography–tandem mass spectrometry: application to a clinical herb–drug interaction study. J Chromatogr B Anal Technol Biomed Life Sci 852:534–544

    Article  CAS  Google Scholar 

  163. Welss T, Basketter DA, Schröder KR (2004) In vitro skin irritation: facts and future. State of the art review of mechanisms and models. Toxicol In Vitro 18:231–243

    Article  CAS  PubMed  Google Scholar 

  164. Wu H, Ramachandran C, Weiner ND, Roessler BJ (2001) Topical transport of hydrophilic compounds using water-in-oil nanoemulsions. Int J Pharm 220:63–75

    Article  CAS  PubMed  Google Scholar 

  165. Yano K, Brown LF, Detmar M (2001) Control of hair growth and follicle size by VEGF-mediated angiogenesis. J Clin Invest 107:409–417

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  166. Yoon JI, Al-Reza SM, Kang SC (2010) Hair growth promoting effect of Zizyphus jujuba essential oil. Food Chem Toxicol 48:1350–1354

    Article  CAS  PubMed  Google Scholar 

  167. Zhang NN, Park DK, Park HJ (2013) Hair growth-promoting activity of hot water extract of Thuja orientalis. BMC Complement Altern Med 13:9

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  168. Zhou SF, Zhou ZW, Li CG, Chen X, Yu X, Xue CC, Herington A (2007) Identification of drugs that interact with herbs in drug development. Drug Discov Today 12:664–673

    Article  CAS  PubMed  Google Scholar 

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  1. Faculty of Cosmetology, The Academy of Cosmetics and Health Care, Podwale 13 Street, 00-252, Warsaw, Poland

    Anna Herman

  2. Department of Genetic Engineering, The Kielanowski Institute of Animal Physiology and Nutrition, Polish Academy of Sciences, Instytucka 3 Street, 05-110, Jablonna, Poland

    Andrzej P. Herman

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Herman, A., Herman, A.P. Topically used herbal products for the treatment of hair loss: preclinical and clinical studies. Arch Dermatol Res 309, 595–610 (2017). https://doi.org/10.1007/s00403-017-1759-7

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