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Archives of Dermatological Research

, Volume 309, Issue 5, pp 381–388 | Cite as

Effect of sinapic acid on hair growth promoting in human hair follicle dermal papilla cells via Akt activation

  • Hyunju Woo
  • Seungjun Lee
  • Seungbeom Kim
  • Deokhoon Park
  • Eunsun Jung
Original Paper

Abstract

Hair loss known as alopecia is caused by abnormal hair follicle cycling including shortening of the anagen (growth) phase and changing of hair follicle morphology with miniaturization. In accordance with the life extension, the quality of life is considered to be a most important thing. The yearning for healthy and beautiful hair and low self esteem due to hair loss had negative influence on the quality of life with psychosocial maladjustment. The objective of this research was to identify new compound that can be used as a drug to promote hair growth. We investigated whether the function of sinapic acid (SA) is able to promote hair growth in human hair follicle dermal papilla cells (hHFDPC). We showed that treatment of SA in hHFDPC could induce proliferation and the activation of Akt signaling in HFDPC. In addition, SA could stimulate the expressions of the several growth factors, insulin-like growth factor 1, and vascular endothelial growth factor for hair growth. We showed that SA led to an increased level of phospho-GSK-3β and β-catenin accumulation in HFDPC. Finally, the promoting effect of SA in hHFDPC cell growth occurred by the induction of cell cycle progression. These results suggest that SA could be one of the potential candidate compounds for the treatment of alopecia by inducing hair growth through triggering the expressions of growth factors via activation of Akt and subsequent inactivation of GSK-3β /β-catenin pathway.

Keywords

Human hair follicle derma papilla cells Sinapic acid Hair growth Wnt/β-catenin signaling pathway 

Notes

Acknowledgements

This research was supported by a Grant (A004600326) from Jeju Economic Region Diagram Industry R&D project Program funded by Jeju Province.

Compliance with ethical standards

Conflict of interest

The authors declare that they have no conflict of interest

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Copyright information

© Springer-Verlag Berlin Heidelberg 2017

Authors and Affiliations

  • Hyunju Woo
    • 1
  • Seungjun Lee
    • 1
  • Seungbeom Kim
    • 1
  • Deokhoon Park
    • 1
  • Eunsun Jung
    • 1
  1. 1.Biospectrum Life Science InstituteSeongnam-siRepublic of Korea

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