Archives of Dermatological Research

, Volume 309, Issue 3, pp 225–228 | Cite as

Psoriasis and cardiovascular events: updating the evidence

Concise Communication
First Online:
Received:
Revised:
Accepted:

Abstract

So far, systematic reviews have suggested an increased risk of cardiovascular diseases (CVD) in psoriatic patients, though some results have been conflicting. The aim of this study was to update the current level of evidence through a systematic search in MEDLINE, EMBASE and Cochrane Central Register databases. In total, 13 high-quality observational studies estimating the incidence of CVD were included. Patients with mild psoriasis had an increased risk of stroke [Hazard ratio (HR) = 1.10, 95% CI: 1.0–1.19] and myocardial infarction (MI) (HR = 1.20, 95% CI: 1.06–1.35), but not cardiovascular death. The risks of both stroke (HR = 1.38, 95% CI: 1.20–1.60), MI (HR = 1.70, 95% CI: 1.18–2.43) and cardiovascular death (HR = 1.37, 95% CI: 1.13–1.67) were increased in patients with severe psoriasis. In conclusion, this updated meta-analysis confirmed that patients with psoriasis have an increased risk of CVD, especially those with severe psoriasis.

Keywords

Psoriasis Myocardial infarction Cardiovascular diseases Meta-analysis Stroke Cardiovascular death 
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Notes

Acknowledgements

The authors would like to thank information specialist Tove Faber Frandsen at the Danish Health Authority for assistance in the literature search.

Compliance with ethical standards

Conflict of interest

The authors declare no conflict of interest.

Funding

The study was initiated and financed by the National Danish Health Authority. URL:https://sundhedsstyrelsen.dk/da/udgivelser/2016/nkr-psoriasis.

Ethical approval

For this type of study formal consent is not required.

Supplementary material

403_2016_1712_MOESM1_ESM.pdf (87 kb)
Supplementary material 1 (PDF 87 KB)
403_2016_1712_MOESM2_ESM.pdf (124 kb)
Supplementary material 2 (PDF 124 KB)
403_2016_1712_MOESM3_ESM.pdf (65 kb)
Supplementary material 3 (PDF 65 KB)

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Copyright information

© Springer-Verlag Berlin Heidelberg 2017

Authors and Affiliations

  1. 1.Department of DermatologyAarhus University HospitalAarhusDenmark
  2. 2.Department of CardiologyOdense University HospitalOdenseDenmark
  3. 3.Department of Clinical MedicineAarhus UniversityAarhusDenmark
  4. 4.Department of RheumatologyAarhus University HospitalAarhusDenmark

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