Archives of Dermatological Research

, Volume 307, Issue 6, pp 505–513 | Cite as

Association of glutathione S-transferase pi (GSTP1) Ile105Val polymorphism with the risk of skin cancer: a meta-analysis

  • Cheng-Fan Zhou
  • Tai Ma
  • Deng-Chuan Zhou
  • Tong Shen
  • Qi-Xing Zhu
Original Paper
First Online:
Received:
Revised:
Accepted:

Abstract

Numerous epidemiological studies have evaluated the association of Glutathione S-transferase P1 (GSTP1) Ile105Val polymorphism with the risk of skin cancer. However, the results remain inconclusive. To derive a more precise estimation of the association between the GSTP1 Ile105Val polymorphism and skin cancer risk, a meta-analysis was performed. A comprehensive search was conducted to identify the eligible studies. We used odds ratios (ORs) with 95 % confidence intervals (CIs) to assess the association of GSTP1 Ile105Val polymorphism with skin cancer risk. Thirteen case–control studies in nine articles, which included a total of 1504 cases and 2243 controls. Overall, we found that GSTP1 Ile105Val polymorphism was not associated with skin cancer risk. Furthermore, subgroup analysis by histological types showed that GSTP1 Ile105Val polymorphism was associated with risks of malignant melanoma under the dominant model (Val/Val + Val/Ile vs. Ile/Ile: OR 1.230, 95 % CI 1.017–1.488, P = 0.033). However, lack of association between GSTP1 Ile105Val polymorphism and BCC and SCC risk in all genetic models. Our meta-analysis suggested that the GSTP1 Ile105Val polymorphism might be associated with increased risk of malignant melanoma in Caucasian population.

Keywords

GSTP1 Gene polymorphism Skin cancer Meta-analysis 
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Notes

Acknowledgments

This work was supported by National Natural Science Foundation of China (81441090, 81371730), the Specialized Research Fund for the Doctoral Program of Higher Education (20133420110001) and Grant for Scientific Research of BSKY (XJ201418) from Anhui Medical University.

Conflict of interest

The authors declare no conflict of interest.

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Copyright information

© Springer-Verlag Berlin Heidelberg 2015

Authors and Affiliations

  • Cheng-Fan Zhou
    • 1
    • 2
  • Tai Ma
    • 3
  • Deng-Chuan Zhou
    • 4
  • Tong Shen
    • 1
    • 2
  • Qi-Xing Zhu
    • 1
    • 2
  1. 1.Department of Occupational Health and Environmental Health, School of Public HealthAnhui Medical UniversityHefeiChina
  2. 2.Institute of Dermatology, the First Affiliated HospitalAnhui Medical UniversityHefeiChina
  3. 3.Department of Oncology, the First Affiliated HospitalAnhui Medical UniversityHefeiChina
  4. 4.Department of Emergency Medicine, the First Affiliated HospitalAnhui Medical UniversityHefeiChina

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