Archives of Dermatological Research

, Volume 305, Issue 2, pp 91–98

Recommendations for detection of individual risk for comorbidities in patients with psoriasis

  • Johannes Wohlrab
  • Gabriele Fiedler
  • Sascha Gerdes
  • Alexander Nast
  • Sandra Philipp
  • Marc A. Radtke
  • Diamant Thaçi
  • Wolfgang Koenig
  • Andreas F. H. Pfeiffer
  • Martin Härter
  • Michael P. Schön
Mini Review

Abstract

Since the pathogenesis of psoriasis vulgaris is now understood as a T cell mediated systemic auto-immune disease, the awareness for the potential systemic implications of the chronic active inflammation has grown. By evaluation of patient registries and study data, several complexes of comorbidities could be identified in recent years, albeit not all of them being clinically relevant. Comorbidity in this context will be defined as two or more diagnostically distinguished medical conditions existing simultaneously, but without a causal link. Nevertheless, there is some strong indication for pathogenetic link between some specified comorbidities and psoriasis at molecular and immunological level. The need for an interdisciplinary assessment of the potential interrelation is obvious. In order to detect the individual risk for comorbidities in patients with moderate to severe psoriasis and to recommend the course of action, a checklist has been developed at an interdisciplinary level that is reduced to the quintessential points for the use in daily practice.

Keywords

Psoriasis Comorbidities 

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Copyright information

© Springer-Verlag Berlin Heidelberg 2013

Authors and Affiliations

  • Johannes Wohlrab
    • 1
  • Gabriele Fiedler
    • 2
  • Sascha Gerdes
    • 3
  • Alexander Nast
    • 4
  • Sandra Philipp
    • 5
  • Marc A. Radtke
    • 6
  • Diamant Thaçi
    • 7
  • Wolfgang Koenig
    • 8
  • Andreas F. H. Pfeiffer
    • 9
  • Martin Härter
    • 10
  • Michael P. Schön
    • 11
  1. 1.Department of Dermatology and VenereologyMartin-Luther-University Halle-WittenbergHalle (Saale)Germany
  2. 2.Dermatological practiceWeißenfelsGermany
  3. 3.Department of DermatologyAllergology and Venereology (Psoriasis-Centre) of University Medical Centre Schleswig-HolsteinKielGermany
  4. 4.Division of Evidence Based Medicine, University Clinic and Policlinic of Dermatology, Allergology and VenereologyCharité, University Medicine BerlinBerlinGermany
  5. 5.University Clinic and Policlinic of Dermatology, Allergology and VenereologyCharité, University Medicine BerlinBerlinGermany
  6. 6.Institute for Health Services Research in Dermatology and NursingUniversity Medical Centre Hamburg-EppendorfHamburgGermany
  7. 7.Department of Dermatology, Venereology and AllergologyJ.W. Goethe University Hospital and Faculty of Medicine Frankfurt am MainFrankfurtGermany
  8. 8.Department of Internal Medicine II—Cardiology, Centre for Internal MedicineUniversity of UlmUlmGermany
  9. 9.Endocrinology, Diabetes and Nutrition MedicineCharité, University Medicine BerlinBerlinGermany
  10. 10.Department of Medical Psychology, Centre for Psychosocial MedicineUniversity Medical Centre Hamburg-EppendorfHamburgGermany
  11. 11.Department of Dermatology, Venereology and AllergologyUniversity Medical Centre GöttingenGöttingenGermany

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