Archives of Dermatological Research

, Volume 305, Issue 2, pp 105–112 | Cite as

Circulating levels of lipocalin-2 and retinol-binding protein-4 are increased in psoriatic patients and correlated with baseline PASI

  • Jorge Romaní
  • Assumpta Caixàs
  • Victoria Ceperuelo-Mallafré
  • José Manuel Carrascosa
  • Miquel Ribera
  • Mercedes Rigla
  • Joan Vendrell
  • Jesús Luelmo
Original Paper


Psoriasis has been related to metabolic syndrome (MS). Adipocytokines produced by white adipose tissue may be involved in the pathogenesis of psoriasis and its association with MS. Our objectives were to characterize the profile of a number of different inflammatory and atherogenic markers, vitamins, adipokines and cytokines and their potential involvement in MS in patients with moderate-to-severe psoriasis without joint involvement compared to anthropometrically matched controls, and to evaluate correlation with severity of the skin disease and changes after narrow-band UVB (NB-UVB) phototherapy. We designed a prospective cross-sectional study. Baseline waist circumference, body fat composition, lipid, carbohydrate and calcium metabolism profile, inflammation markers, homocysteine and vitamins D, B6, B12 and folic acid, leptin, resistin, omentin, lipocalin-2, adipocyte fatty acid-binding protein, retinol-binding protein-4 (RBP-4), interleukin-6, soluble tumour necrosis factor receptor 1 (sTNFR1) and interleukin-17 of 50 psoriasis patients and 50 gender, age and body mass index-matched controls were recorded, then evaluated after NB-UVB in the patients. The patients had higher baseline serum concentrations of leptin, RBP-4, lipocalin-2 and sTNFR1. Baseline psoriasis area and severity index correlated with serum concentrations of RBP-4 and lipocalin-2 only. Principal components analysis disclosed a component including vitamins B12, B6, folic acid, calcidiol and HDL-cholesterol that was only present in healthy controls and opposed to a cluster of variables which promote MS. This component was absent in the patients. Our results point to lipocalin-2 and RBP-4 as relevant mediators of the trend towards MS in psoriatic patients.


Psoriasis Adipokines Phototherapy Comorbidities Metabolic syndrome 



This study was financially supported by a research grant from the Comite Institucional de Recerca of the Fundació Parc Taulí. The sponsors had no role in the design and conduct of the study; in the collection, analysis and interpretation of data; or in the preparation, review or approval of the manuscript.

Conflict of interest



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Copyright information

© Springer-Verlag Berlin Heidelberg 2012

Authors and Affiliations

  • Jorge Romaní
    • 1
    • 6
  • Assumpta Caixàs
    • 2
  • Victoria Ceperuelo-Mallafré
    • 3
  • José Manuel Carrascosa
    • 5
  • Miquel Ribera
    • 1
  • Mercedes Rigla
    • 2
  • Joan Vendrell
    • 4
  • Jesús Luelmo
    • 1
  1. 1.Department of Dermatology, Hospital Universitari Parc Taulí, Hospital de Sabadell, Corporació Sanitària Parc Taulí, Institut Universitari Parc Taulí, UABUniversitat Autònoma de BarcelonaBellaterraSpain
  2. 2.Department of Diabetes, Endocrinology and Nutrition, Hospital Universitari Parc Taulí, Hospital de Sabadell, Corporació Sanitària Parc Taulí, Institut Universitari Parc Taulí, UABUniversitat Autònoma de BarcelonaBellaterraSpain
  3. 3.Centro de Investigación Biomédica en Red-Fisiopatología de la Obesidad y la Nutrición (CIBERobn)Hospital Clínico Virgen de la VictoriaMálagaSpain
  4. 4.Department of EndocrinologyHospital Universitari Joan XXIIITarragonaSpain
  5. 5.Department of Dermatology, Hospital Universitari Germans Trias i PujolUniversitat Autònoma de BarcelonaBadalonaSpain
  6. 6.Hospital Parc TaulíSabadellSpain

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