Archives of Dermatological Research

, Volume 305, Issue 3, pp 233–239

Possible contribution of GSTP1 and other xenobiotic metabolizing genes to vitiligo susceptibility

  • Mikhail M. Minashkin
  • Lubov E. Salnikova
  • Konstantin M. Lomonosov
  • Igor V. Korobko
  • Andrey O. Tatarenko
Original Paper

Abstract

Vitiligo is an acquired pigmentary disorder with several proposed pathogenesis mechanisms and complex multifactorial genetic predisposition. We analyzed 65 polymorphisms in genes potentially relevant to vitiligo pathogenesis mechanism to reveal novel and confirm reported genetic risk factors in general Russian population. We found that polymorphism rs1138272 (TC + CC) in GSTP1 gene encoding enzyme involved in xenobiotic metabolism is associated with vitiligo (Bonferroni adjusted P value 0.0015) with extraordinary high odds ratio 13.03, and haplotype analysis confirmed association of GSTP1 gene with vitiligo risk. Moreover, analysis of variations in several genes encoding enzymes of xenobiotic metabolism showed that higher risk of vitiligo is associated with higher number of risk alleles. This finding reveals possible contribution of genetic background to observed imbalance of oxidative stress control in vitiligo through cumulative effect of multiple genetic variations in xenobiotic metabolizing genes, supporting the concept of multigenic nature of vitiligo with multiple low-risk alleles cumulatively contributing to vitiligo risk.

Keywords

Vitiligo Genetic susceptibility Case–control study GSTP1 gene polymorphism Xenobiotic metabolizing genes 

Supplementary material

403_2012_1301_MOESM1_ESM.pdf (200 kb)
Supplementary material 1 (PDF 199 kb)

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Copyright information

© Springer-Verlag Berlin Heidelberg 2012

Authors and Affiliations

  • Mikhail M. Minashkin
    • 1
  • Lubov E. Salnikova
    • 2
    • 3
  • Konstantin M. Lomonosov
    • 5
  • Igor V. Korobko
    • 2
    • 4
  • Andrey O. Tatarenko
    • 1
  1. 1.Center for Innovative Biotechnologies “Allele”MoscowRussia
  2. 2.Institute of Gene BiologyRussian Academy of SciencesMoscowRussia
  3. 3.N.I. Vavilov Institute of General GeneticsRussian Academy of SciencesMoscowRussia
  4. 4.Vitiligo Research FoundationNew YorkUSA
  5. 5.Department of Skin and Venereal DiseasesI.M. Sechenov Moscow Medical AcademyMoscowRussia

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