Archives of Dermatological Research

, Volume 304, Issue 10, pp 787–793 | Cite as

Interactions between FLG mutations and allergens in atopic dermatitis

Original Paper


Filaggrin gene (FLG) mutations and sensitization in patients with atopic dermatitis (AD) have been well documented. However, whether an interaction exists between these mutations and specific sensitization in AD patients is still unknown. The aim of the study was to explore the interaction between FLG mutations and specific sensitization in AD patients. A total of 249 AD outpatients were recruited in the current study. Skin prick tests were conducted to assess the patient’s sensitization to specific allergens. FLG mutations were analyzed through comprehensive sequencing. Logistic regression analyses were conducted to determine the interactions between FLG mutations and sensitization present. The mean age of the patients was 3.5 years, and the mean age of onset of AD was 9.6 months. The mean SCORAD of the patients was 25.8. Fourteen types of mutations were identified in the FLG of 64 patients. A total of 24 (9.6 %) and 29 (11.6 %) cases were mutated with 3321delA and K4671X, respectively. Sensitization to at least one type of allergen was detected in 118 patients (47.4 %). Logistic regression analyses showed that FLG mutations presented an interaction with sensitization to peanut and did not interact with the other detected allergens among AD patients. Sensitization to peanut allergens would have an interaction with the mutation of K4671X and the combined mutations in FLG in patients with atopic dermatitis. However, sensitization to the other common allergens might not interact with FLG mutations in the development of atopic dermatitis.


Atopic dermatitis Filaggrin gene Mutations Sensitization Allergen 


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Copyright information

© Springer-Verlag 2012

Authors and Affiliations

  1. 1.Department of Dermatology, Xinhua HospitalShanghai Jiaotong University School of MedicineShanghaiChina
  2. 2.Department of DermatologyBao’an Maternal and Child Health HospitalShenzhenChina
  3. 3.Department of DermatologyShanxi Provincial Children’s HospitalTaiyuanChina
  4. 4.Central Laboratory, Bao’an Maternal and Child Health HospitalShenzhenChina

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