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Archives of Dermatological Research

, Volume 304, Issue 10, pp 823–830 | Cite as

Over-expression of tumor necrosis factor-α in vitiligo lesions after narrow-band UVB therapy: an immunohistochemical study

  • Enayat AttwaEmail author
  • Hend Gamil
  • Magda Assaf
  • Sohair Ghonemy
Original Paper

Abstract

There is a growing evidence that cytokines are important in the depigmentation process of vitiligo, however, the exact mechanism is not fully understood. The aim of this work was to study the possible role of the tumor necrosis factor-α (TNF-α) cytokine in the depigmentation process of the disease. Twenty patients with generalized vitiligo were exposed to narrow-band ultraviolet B (NB-UVB) therapy thrice weekly for a total of 60 sessions. Immunohistochemical examination was done, to assess the TNF-α expression in lesional and perilesional skin as compared to normal control skin, before and after therapy. At baseline, positive lesional TNF-α expression was detected in 60 % of patients which was significantly higher as compared to perilesional skin (20 %) and negative expression in healthy control skin. Post-treatment, a statistically significant increase in TNF-α expression was detected in both lesional (90 %) and perilesional skin (70 %) as compared to baseline (P < 0.05). The significant increase of TNF-α in vitiligo lesions compared with perilesional and healthy skin suggests a possible involvement of this cytokine in the depigmentation of vitiligo. The increase in TNF-α expression after NB-UVB phototherapy suggests another role in repigmentation.

Keywords

Narrow-band ultraviolet B Tumor necrosis factor-α Vitiligo 

Notes

Conflict of interest

None declared.

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Copyright information

© Springer-Verlag 2012

Authors and Affiliations

  • Enayat Attwa
    • 1
    Email author
  • Hend Gamil
    • 1
  • Magda Assaf
    • 1
  • Sohair Ghonemy
    • 1
  1. 1.Departments of Dermatology, Venereology and Pathology, Faculty of MedicineZagazig UniversityZagazigEgypt

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