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Archives of Dermatological Research

, Volume 305, Issue 2, pp 173–177 | Cite as

Elevated serum interleukin-33 levels in patients with Henoch-Schönlein purpura

  • Tao Chen
  • Rui-zhen Jia
  • Zai-pei GuoEmail author
  • Na Cao
  • Meng-meng Li
  • Xiao-yan Jiao
Short Communication

Abstract

Henoch-Schönlein purpura (HSP) is the most common systemic vasculitis and is known as an immunoglobulin (Ig) A related immune complex-mediated disease. However, the molecular mechanisms in the development of HSP are not yet fully understood. Herein, we investigated the serum levels of Interleukin (IL)-33 and soluble ST2 (sST2) in HSP patients and their association with disease severity and IgA autoantibodies production. The serum levels of IL-33 and sST2 were measured by double antibody sandwich enzyme-linked immunosorbent assay (ELISA) in the serum of 33 patients with HSP and 22 controls. Serum levels of IgA anti-endothelial cell antibodies (AECA) and IgA anticardiolipin antibodies (ACA) in HSP patients were detected by double antigen sandwich ELISA. Our results indicated that serum levels of IL-33 but not sST2 were significantly elevated in patients with HSP in acute stage and restored to normal levels in convalescent stage. Moreover, serum IL-33 levels were correlated with the severity of HSP and serum concentrations of AECA-IgA and ACA-IgA. Taken together, we show firstly that serum IL-33 is abnormally elevated in HSP patients. IL-33 might be associated with the IgA autoantibodies production in the pathogenesis of HSP.

Keywords

Henoch-Schonlein purpura Interleukin-33 Soluble ST2 Anti-endothelial cell antibodies IgA Anticardiolipin antibodies IgA 

Notes

Acknowledgments

This study was supported with grants from Natural Science Foundation of China (81101198).

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Copyright information

© Springer-Verlag 2012

Authors and Affiliations

  • Tao Chen
    • 1
  • Rui-zhen Jia
    • 2
  • Zai-pei Guo
    • 1
    Email author
  • Na Cao
    • 1
  • Meng-meng Li
    • 1
  • Xiao-yan Jiao
    • 1
  1. 1.Department of DermatovenereologyWest China Hospital of Sichuan UniversityChengduChina
  2. 2.Open LaboratoryWest China Second Hospital of Sichuan UniversityChengduChina

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