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Archives of Dermatological Research

, Volume 304, Issue 6, pp 451–457 | Cite as

Role of cellular oxidative stress and cytochrome c in the pathogenesis of psoriasis

  • Sami A. Gabr
  • Ahmad H. Al-Ghadir
Original Paper

Abstract

Oxidative-free radicals and apoptosis have linked to chronic skin diseases. Higher levels of oxidative radicals and the release of mitochondrial cytochrome c may have a role in the pathogenesis of psoriasis. We investigated the possible role of cellular oxidative stress and release of cytochrome c of mitochondria in the pathogenesis of psoriasis. Disease severity was assessed by psoriasis area severity index score (PASI) of 55 psoriasis patients, they grouped as mild (11), moderate (20) and severe (24), also 20 healthy individuals used as controls. All groups were subjected for serum malondialdehyde (MDA), nitric oxide (NO·), superoxide dismutase (SOD), catalase (CAT), total antioxidant status (TAS) and serum cytochrome c concentrations. We found that, (1) Severity wise increase in MDA and NO·, and decrease in SOD, CAT and TAS levels in all patients with different degrees of psoriasis; (2) PASI showed positive correlation with the increase in MDA and NO·, and negatively with decreased SOD, CAT and TAS levels; (3) significant increase in cytochrome c level was observed among psoriasis patients which showed negative correlation to MDA and NO· levels in mild and positively with moderate and severe groups. The release of mitochondrial cytochrome c indicates the induction of apoptosis mediated via oxidative stress which ultimately plays role in the pathogenesis of psoriasis.

Keywords

Mitochondria Psoriasis PASI score Apoptosis cytochrome c Oxidative stress Antioxidant status Antioxidant enzymes 

Notes

Conflict of interest

The authors declare that they have no conflict of interest.

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Copyright information

© Springer-Verlag 2012

Authors and Affiliations

  1. 1.Department of Anatomy, Faculty of MedicineMansoura UniversityMansouraEgypt
  2. 2.Rehabilitation Research Chair (RRC)King Saud UniversityRiyadhSaudi Arabia
  3. 3.Department of Rehabilitation Science, College of Applied Medical SciencesKing Saud UniversityRiyadhSaudi Arabia

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