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Archives of Dermatological Research

, Volume 304, Issue 2, pp 119–125 | Cite as

Psoriasis increased the risk of diabetes: a meta-analysis

  • Juan ChengEmail author
  • Dayu Kuai
  • Li Zhang
  • Xueqin Yang
  • Bing Qiu
Original Paper

Abstract

To evaluate the association between psoriasis and risk of diabetes, pertinent studies were identified by searching electronic databases and by reviewing the reference lists of retrieved articles. We included observational studies that examined the association between psoriasis and risk of diabetes. Two reviewers independently assessed eligibility and used a standardized form to collect data from published studies. The study quality was assessed by the Newcastle–Ottawa Scale. A total of 22 eligible studies that included 3,307,516 participants fulfilled the inclusion criteria. Compared to individuals without psoriasis, subjects with psoriasis had a 1.42-fold increased risk of diabetes (95% CI, 1.40–1.45). Findings from this meta-analysis suggest that individuals with psoriasis may have a modestly increased risk of diabetes.

Keywords

Diabetes Psoriasis Meta-analysis 

Notes

Acknowledgments

This research was supported by the Institute of Medical Information & Library, Chinese Academy of Medical Sciences and Peking Union Medical College (CAMS & PUMC).

Conflict of interest

No conflict of interest existed for any of the authors.

References

  1. 1.
    Alexander E, Pinto J, Pal GS, Kamath N, Kuruvilla M (2001) Disease concomitance in psoriasis: a clinical study of 61 cases. Indian J Dermatol Venereol Leprol 67:66–68PubMedGoogle Scholar
  2. 2.
    Al-Mutairi N, Al-Farag S, Al-Mutairi A, Al-Shiltawy M (2010) Comorbidities associated with psoriasis: an experience from the Middle East. J Dermatol 37:146–155PubMedCrossRefGoogle Scholar
  3. 3.
    Augustin M, Glaeske G, Radtke MA, Christophers E, Reich K, Schäfer I (2010) Epidemiology and comorbidity of psoriasis in children. Br J Dermatol 162:633–636PubMedCrossRefGoogle Scholar
  4. 4.
    Boehncke S, Fichtlscherer S, Salgo R, Garbaraviciene J, Beschmann H, Diehl S, Hardt K, Thaçi D, Boehncke WH (2011) Systemic therapy of plaque-type psoriasis ameliorates endothelial cell function: results of a prospective longitudinal pilot trial. Arch Dermatol Res 303:381–388PubMedCrossRefGoogle Scholar
  5. 5.
    Boehncke WH, Boehncke S, Tobin AM, Kirby B (2011) The ‘psoriatic march’: a concept of how severe psoriasis may drive cardiovascular comorbidity. Exp Dermatol 20:303–307PubMedCrossRefGoogle Scholar
  6. 6.
    Boehncke WH, Boehncke S, Schon MP (2010) Managing comorbid disease in patients with psoriasis. BMJ 340:b5666PubMedCrossRefGoogle Scholar
  7. 7.
    Blettner M, Sauerbrei W, Schlehofer B, Scheuchenpflug T, Friedenreich C (1999) Traditional reviews, meta-analyses and pooled analyses in epidemiology. Int J Epidemiol 28:1–9PubMedCrossRefGoogle Scholar
  8. 8.
    Brauchli YB, Jick SS, Meier CR (2008) Psoriasis and the risk of incident diabetes mellitus: a population-based study. Br J Dermatol 159:1331–1337PubMedCrossRefGoogle Scholar
  9. 9.
    Chen YJ, Wu CY, Shen JL, Chu SY, Chen CK, Chang YT, Chen CM (2008) Psoriasis independently associated with hyperleptinemia contributing to metabolic syndrome. Arch Dermatol 144:1571–1575PubMedCrossRefGoogle Scholar
  10. 10.
    Cohen AD, Dreiher J, Shapiro Y, Vidavsky L, Vardy DA, Davidovici B, Meyerovitch J (2008) Psoriasis and diabetes: a population-based cross-sectional study. J Eur Acad Dermatol Venereol 22:585–589PubMedCrossRefGoogle Scholar
  11. 11.
    Das SK, Elbein SC (2007) The search for type 2 diabetes susceptibility loci: the chromosome 1q story. Curr Diab Rep 7:154–164PubMedCrossRefGoogle Scholar
  12. 12.
    Ding EL, Hu FB (2007) Smoking and type 2 diabetes: under recognized risks and disease burden. JAMA 298:2675–2676PubMedCrossRefGoogle Scholar
  13. 13.
    Driessen RJ, Boezeman JB, Van de Kerkhof PC, De Jong EM (2009) Cardiovascular risk factors in high-need psoriasis patients and its implications for biological therapies. J Dermatol Treat 20:42–47CrossRefGoogle Scholar
  14. 14.
    Foy CG, Bell RA, Farmer DF, Goff DC Jr, Wagenknecht LE (2005) Smoking and incidence of diabetes among U.S. adults:findings from the Insulin Resistance Atherosclerosis Study. Diabetes Care 28:2501–2507PubMedCrossRefGoogle Scholar
  15. 15.
    Fuller JH, Stevens LK, Wang SL (2001) Risk factors for cardiovascular mortality and morbidity: the WHO Mutinational Study of Vascular Disease in Diabetes. Diabetologia 44 (Suppl 2):S54–S64PubMedCrossRefGoogle Scholar
  16. 16.
    Gelfand JM, Weinstein R, Porter SB, Neimann AL, Berlin JA, Margolis DJ (2005) Prevalence and treatment of psoriasis in the United Kingdom: a population-based study. Arch Dermatol 141:1537–1541PubMedCrossRefGoogle Scholar
  17. 17.
    Gerdes S, Zahl VA, Knopf H, Weichenthal M, Mrowietz U (2008) Comedication related to comorbidities: a study in 1203 hospitalized patients with severe psoriasis. Br J Dermatol 159:1116–1123PubMedGoogle Scholar
  18. 18.
    Gisondi P, Tessari G, Conti A, Piaserico S, Schianchi S, Peserico A, Giannetti A, Girolomoni G (2007) Prevalence of metabolic syndrome in patients with psoriasis: a hospital-based case-control study. Br J Dermatol 157:68–73PubMedCrossRefGoogle Scholar
  19. 19.
    Hill MJ, Metcalfe D, McTernan PG (2009) Obesity and diabetes: lipids, ‘nowhere to run to’. Clin Sci (Lond) 116:113–123CrossRefGoogle Scholar
  20. 20.
    Huerta C, Rivero E, Rodríguez LA (2007) Incidence and risk factors for psoriasis in the general population. Arch Dermatol 143:1559–1565PubMedCrossRefGoogle Scholar
  21. 21.
    Kaye JA, Li L, Jick SS (2008) Incidence of risk factors for myocardial infarction and other vascular diseases in patients with psoriasis. Br J Dermatol 159:895–902PubMedCrossRefGoogle Scholar
  22. 22.
    Kimball AB, Robinson D Jr, Wu Y, Guzzo C, Yeilding N, Paramore C, Fraeman K, Bala M (2008) Cardiovascular disease and risk factors among psoriasis patients in two US healthcare databases, 2001–2002. Dermatology 217:27–37PubMedCrossRefGoogle Scholar
  23. 23.
    Meigs JB, Wilson PW, Fox CS, Vasan RS, Nathan DM, Sullivan LM, D’Agostino RB (2006) Body mass index, metabolic syndrome, and risk of type 2 diabetes or cardiovascular disease. J Clin Endocrinol Metab 91:2906–2912PubMedCrossRefGoogle Scholar
  24. 24.
    Mokdad AH, Ford ES, Bowman BA, Dietz WH, Vinicor F, Bales VS, Marks JS (2003) Prevalence of obesity, diabetes, and obesity-related health risk factors 2001. JAMA 289:76–79PubMedCrossRefGoogle Scholar
  25. 25.
    Naldi L, Chatenoud L, Belloni A, Peserico A, Balato N, Virgili AR, Bruni PL, Ingordo V, Lo Scocco G, Solaroli C, Schena D, Di Landro A, Pezzarossa E, Arcangeli F, Gianni C, Betti R, Carli P, Farris A, Barabino GF, La Vecchia C, Parazzini F (2008) Medical history, drug exposure and the risk of psoriasis. Evidence from an Italian case-control study. Dermatology 216:125–130PubMedCrossRefGoogle Scholar
  26. 26.
    Neimann AL, Shin DB, Wang X, Margolis DJ, Troxel AB, Gelfand JM (2006) Prevalence of cardiovascular risk factors in patients with psoriasis. J Am Acad Dermatol 55:829–835PubMedCrossRefGoogle Scholar
  27. 27.
    Ng MC, Miyake K, So WY, Poon EW, Lam VK, Li JK, Cox NJ, Bell GI, Chan JC (2005) The linkage and association of the gene encoding upstream stimulatory factor 1 with type 2 diabetes and metabolic syndrome in the Chinese population. Diabetologia 48:2018–2024PubMedCrossRefGoogle Scholar
  28. 28.
    Prodanovich S, Kirsner RS, Kravetz JD, Ma F, Martinez L, Federman DG (2009) Association of psoriasis with coronary artery, cerebrovascular and peripheral vascular diseases and mortality. Arch Dermatol 145:700–703PubMedCrossRefGoogle Scholar
  29. 29.
    Qureshi AA, Choi HK, Setty AR, Curhan GC (2009) Psoriasis and the risk of diabetes and hypertension: a prospective study of US female nurses. Arch Dermatol 145:379–382PubMedCrossRefGoogle Scholar
  30. 30.
    Rapp SR, Feldman SR, Exum ML, Fleischer AB Jr, Reboussin DM (1999) Psoriasis causes as much disability as other major medical diseases. J Am Acad Dermatol 41:401–407PubMedCrossRefGoogle Scholar
  31. 31.
    Schmitt J, Ford DE (2010) Psoriasis is independently associated with psychiatric morbidity and adverse cardiovascular risk factors, but not with cardiovascular events in a population-based sample. J Eur Acad Dermatol Venereol 24:885–892PubMedCrossRefGoogle Scholar
  32. 32.
    Shapiro J, Cohen AD, David M, Hodak E, Chodik G, Viner A, Kremer E, Heymann A (2007) The association between psoriasis, diabetes mellitus, and atherosclerosis in Israel: a case–control study. J Am Acad Dermatol 56:629–634PubMedCrossRefGoogle Scholar
  33. 33.
    Sommer DM, Jenisch S, Suchan M, Christophers E, Weichenthal M (2006) Increased prevalence of the metabolic syndrome in patients with moderate to severe psoriasis. Arch Dermatol Res 298:321–328PubMedCrossRefGoogle Scholar
  34. 34.
    Srinivas M, Narayana P, Surender T, Krishna DR (2008) Study of insulin resistance in relation to serum IGF-I levels in treated type-II diabetic patients. J Assoc Physicians India 56:645–646PubMedGoogle Scholar
  35. 35.
    Steinthorsdottir V, Thorleifsson G, Reynisdottir I, Benediktsson R, Jonsdottir T, Walters GB, Styrkarsdottir U, Gretarsdottir S, Emilsson V, Ghosh S, Baker A, Snorradottir S, Bjarnason H, Ng MC, Hansen T, Bagger Y, Wilensky RL, Reilly MP, Adeyemo A, Chen Y, Zhou J, Gudnason V, Chen G, Huang H, Lashley K, Doumatey A, So WY, Ma RC, Andersen G, Borch-Johnsen K, Jorgensen T, van Vliet-Ostaptchouk JV, Hofker MH, Wijmenga C, Christiansen C, Rader DJ, Rotimi C, Gurney M, Chan JC, Pedersen O, Sigurdsson G, Gulcher JR, Thorsteinsdottir U, Kong A, Stefansson K (2007) A variant in CDKAL1 influences insulin response and risk of type 2 diabetes. Nat Genet 39:770–775PubMedCrossRefGoogle Scholar
  36. 36.
    Stern RS, Nijsten T, Feldman SR, Margolis DJ, Rolstad T (2004) Psoriasis is common, carries a substantial burden even when not extensive, and is associated with widespread treatment dissatisfaction. J Investig Dermatol Symp Proc 9:136–139PubMedCrossRefGoogle Scholar
  37. 37.
    Vena GA, Altomare G, Ayala F, Berardesca E, Calzavara-Pinton P, Chimenti S, Giannetti A, Girolomoni G, Lotti T, Martini P, Mazzaglia G, Peserico A, Puglisi Guerra A, Sini G, Cassano N, Cricelli C (2010) Incidence of psoriasis and association with comorbidities in Italy: a 5-year observational study from a national primary care database. Eur J Dermatol 20:593–598PubMedGoogle Scholar
  38. 38.
    Wannamethee SG, Shaper AG, Lennon L, Morris RW (2005) Metabolic syndrome vs. Framingham Risk Score for prediction of coronary heart disease, stroke, and type 2 diabetes mellitus. Arch Intern Med 165:2644–2650PubMedCrossRefGoogle Scholar
  39. 39.
    Stang A (2010) Critical evaluation of the Newcastle–Ottawa scale for the assessment of the quality of nonrandomized studies in meta-analyses. Eur J Epidemiol 25:603–605PubMedCrossRefGoogle Scholar
  40. 40.
    Wolf N, Quaranta M, Prescott NJ, Allen M, Smith R, Burden AD, Worthington J, Griffiths CE, Mathew CG, Barker JN, Capon F, Trembath RC (2008) Psoriasis is associated with pleiotropic susceptibility loci identified in type II diabetes and Crohn disease. J Med Genet 45:114–116PubMedCrossRefGoogle Scholar
  41. 41.
    Xiao J, Chen LH, Tu YT, Deng XH, Tao J (2009) Prevalence of myocardial infarction in patients with psoriasis in central China. J Eur Acad Dermatol Venereol 23:1311–1315PubMedCrossRefGoogle Scholar
  42. 42.
    Yoo H, Kim S-J, Kim Y, Lee H, Kim TY (2007) Insulin-like growth factor-II regulates the 12-lipoxygenase gene expression and promotes cell proliferation in human keratinocytes via the extracellular regulatory kinase and phosphatidylinositol 3-kinase pathways. Int J Biochem Cell Biol 39:1248–1259PubMedCrossRefGoogle Scholar

Copyright information

© Springer-Verlag 2011

Authors and Affiliations

  • Juan Cheng
    • 1
    Email author
  • Dayu Kuai
    • 2
  • Li Zhang
    • 3
  • Xueqin Yang
    • 4
  • Bing Qiu
    • 5
  1. 1.Department of DermatologyBeijing 302 HospitalBeijingChina
  2. 2.Department of DigestionLu He HospitalBeijingChina
  3. 3.Department of DermatologyBeijing 307 HospitalBeijingChina
  4. 4.Department of DermatologyAir Force General HospitalBeijingChina
  5. 5.Civil Aviation Medicine Center of Civil Aviation Administration of ChinaBeijingChina

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