Archives of Dermatological Research

, Volume 303, Issue 10, pp 691–705

Innate immunity in the pathogenesis of psoriasis

Review Article


Psoriasis is a common, immune-mediated inflammatory skin disorder. T helper(h)1 and Th17 lymphocytes contribute to the pathogenesis of psoriasis through the release of inflammatory cytokines that promote further recruitment of immune cells, keratinocyte proliferation and sustained inflammation. The innate immune system is the first line of defence against infection and plays a crucial role in the initiation of the adaptive immune response. The presence of innate immune cells and their products in psoriatic skin plaques suggests a role for innate immunity in this disease. In addition, the innate immune system can direct the development of pathogenic Th cells in psoriasis. In this article, we will summarise the role of the innate immune system in psoriasis with particular emphasis on the role of cytokines, signalling pathways and cells of the innate immune system.


Psoriasis Innate immunity Inflammation T cells 

Copyright information

© Springer-Verlag 2011

Authors and Affiliations

  • Cheryl M. Sweeney
    • 2
  • Ann-Marie Tobin
    • 1
  • Brian Kirby
    • 1
  1. 1.Department of DermatologySt. Vincent’s University HospitalDublin 4Ireland
  2. 2.Department of Dermatology, Education and Research CentreSt Vincent’s University HospitalDublin 4Ireland

Personalised recommendations