Promoter polymorphisms of the HLA-G gene, but not the HLA-E and HLA-F genes, is associated with non-segmental vitiligo patients in the Korean population

  • Su Kang Kim
  • Mi Sook Hong
  • Min Kyung Shin
  • Yoon Kyung Uhm
  • Joo-Ho Chung
  • Mu-Hyoung Lee
Short Communication

Abstract

The aim of this study was to determine whether or not promoter polymorphisms of the class I major histocompatibility complex (HLA-E, HLA-F, and HLA-G) are associated with susceptibility to vitiligo. To identify a possible association with vitiligo, 241 patients with non-segmental vitiligo (NSV) and 395 healthy controls were recruited in this study. Three promoter single nucleotide polymorphisms (SNPs; rs1264459 of HLA-E, rs9258170 of HLA-F, and rs1736936 of HLA-G) were analyzed using a polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) technique and direct sequencing. Multiple logistic regression models (co-dominant 1, co-dominant 2, dominant, recessive, and log-additive models) were applied for odds ratios (ORs), 95% confidence intervals (CIs), and P values. To obtain the defined results, P values were recalculated by a Bonferroni correction. After the Bonferroni correction, the genotype of the SNP (rs1736936) of HLA-G was shown to have significant association with NSV (P = 0.045 in the recessive model). The genotype frequencies of the HLA-G SNP (rs1736936) had a significant correlation with the age of onset of NSV (P = 0.016 in the co-dominant 1 model and P = 0.027 in the dominant model). Our results suggest that HLA-G, but not HLA-E and HLA-F, may be associated with susceptibility to NSV in the Korean population.

Keywords

Major histocompatibility complex, class I MHC Non-classical MHC Single nucleotide polymorphism Non-segmental vitiligo 

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Copyright information

© Springer-Verlag 2011

Authors and Affiliations

  • Su Kang Kim
    • 1
  • Mi Sook Hong
    • 1
  • Min Kyung Shin
    • 2
  • Yoon Kyung Uhm
    • 3
  • Joo-Ho Chung
    • 1
  • Mu-Hyoung Lee
    • 2
  1. 1.Kohwang Medical Research Institute, School of MedicineKyung Hee UniversitySeoulRepublic of Korea
  2. 2.Department of Dermatology, School of MedicineKyung Hee UniversitySeoulRepublic of Korea
  3. 3.Department of Clinical Pharmacology, School of MedicineKyung Hee UniversitySeoulRepublic of Korea

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