Archives of Dermatological Research

, Volume 303, Issue 4, pp 239–246 | Cite as

Polyhydroxylated fatty alcohols derived from avocado suppress inflammatory response and provide non-sunscreen protection against UV-induced damage in skin cells

  • Gennady Rosenblat
  • Shai Meretski
  • Joseph Segal
  • Mark Tarshis
  • Avi Schroeder
  • Alexandra Zanin-Zhorov
  • Gilead Lion
  • Arieh Ingber
  • Malka Hochberg
Original Paper

Abstract

Exposing skin to ultraviolet (UV) radiation contributes to photoaging and to the development of skin cancer by DNA lesions and triggering inflammatory and other harmful cellular cascades. The present study tested the ability of unique lipid molecules, polyhydroxylated fatty alcohols (PFA), extracted from avocado, to reduce UVB-induced damage and inflammation in skin. Introducing PFA to keratinocytes prior to their exposure to UVB exerted a protective effect, increasing cell viability, decreasing the secretion of IL-6 and PGE2, and enhancing DNA repair. In human skin explants, treating with PFA reduced significantly UV-induced cellular damage. These results support the idea that PFA can play an important role as a photo-protective agent in UV-induced skin damage.

Keywords

UVB Photodamage UVB-damaged cells Non-sunscreen protection Avocado extract Polyhydroxylated fatty alcohols 

Supplementary material

403_2010_1088_MOESM1_ESM.pdf (39 kb)
Figure 1. Retention time (a) and GC-elution profile of polyhydroxylated fatty alcohols from avocado seed (b) and avocado pear (c). *Numbers in table correspond to the molecule marked with the same number in Fig.1 **retention time
403_2010_1088_MOESM2_ESM.pdf (12 kb)
Figure 2. UV absorption spectrum of PFA

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Copyright information

© Springer-Verlag 2010

Authors and Affiliations

  • Gennady Rosenblat
    • 1
  • Shai Meretski
    • 1
  • Joseph Segal
    • 1
  • Mark Tarshis
    • 2
  • Avi Schroeder
    • 3
  • Alexandra Zanin-Zhorov
    • 4
  • Gilead Lion
    • 5
  • Arieh Ingber
    • 5
  • Malka Hochberg
    • 5
  1. 1.Polyol Biotech LtdGranot Initiative CenterD.N. HeferIsrael
  2. 2.School of MedicineHebrew UniversityJerusalemIsrael
  3. 3.Koch Institute of Integrative Cancer ResearchMassachusetts Institute of TechnologyCambridgeUSA
  4. 4.School of MedicineNew York UniversityNew YorkUSA
  5. 5.Department of DermatologyHebrew University-Hadassah Medical CenterJerusalemIsrael

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