Archives of Dermatological Research

, Volume 302, Issue 2, pp 71–83

Skin photoprotection by natural polyphenols: anti-inflammatory, antioxidant and DNA repair mechanisms

Mini Review

Abstract

Epidemiological, clinical and laboratory studies have implicated solar ultraviolet (UV) radiation in various skin diseases including, premature aging of the skin and melanoma and non-melanoma skin cancers. Chronic UV radiation exposure-induced skin diseases or skin disorders are caused by the excessive induction of inflammation, oxidative stress and DNA damage, etc. The use of chemopreventive agents, such as plant polyphenols, to inhibit these events in UV-exposed skin is gaining attention. Chemoprevention refers to the use of agents that can inhibit, reverse or retard the process of these harmful events in the UV-exposed skin. A wide variety of polyphenols or phytochemicals, most of which are dietary supplements, have been reported to possess substantial skin photoprotective effects. This review article summarizes the photoprotective effects of some selected polyphenols, such as green tea polyphenols, grape seed proanthocyanidins, resveratrol, silymarin and genistein, on UV-induced skin inflammation, oxidative stress and DNA damage, etc., with a focus on mechanisms underlying the photoprotective effects of these polyphenols. The laboratory studies conducted in animal models suggest that these polyphenols have the ability to protect the skin from the adverse effects of UV radiation, including the risk of skin cancers. It is suggested that polyphenols may favorably supplement sunscreens protection, and may be useful for skin diseases associated with solar UV radiation-induced inflammation, oxidative stress and DNA damage.

Keywords

Interleukin DNA repair Antioxidant Anti-inflammation Polyphenols Ultraviolet radiation Cyclooxygenase-2 

Abbreviations

COX-2

Cyclooxygenase-2

EGCG

Epigallocatechin-3-gallate

GSPs

Grape seed proanthocyanidins

GTPs

Green tea polyphenols

IL

Interleukin

NER

Nucleotide excision repair

NFκB

Nuclear factor-kappaB

UV

Ultraviolet

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Copyright information

© Springer-Verlag 2009

Authors and Affiliations

  1. 1.Department of DermatologyUniversity of Alabama at BirminghamBirminghamUSA
  2. 2.Clinical Nutrition Research CenterUniversity of Alabama at BirminghamBirminghamUSA
  3. 3.Comprehensive Cancer CenterUniversity of Alabama at BirminghamBirminghamUSA
  4. 4.Birmingham Veterans Administration Medical CenterBirminghamUSA

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