Archives of Dermatological Research

, Volume 301, Issue 1, pp 83–86

Type I interferon-associated cytotoxic inflammation in cutaneous lupus erythematosus

  • Joerg Wenzel
  • Sabine Zahn
  • Thomas Bieber
  • Thomas Tüting
Review

Abstract

Inappropriate activation of innate immune mechanisms, in particular of the type I interferon (IFN) system, is regarded to play an important role in the pathogenesis of lupus erythematosus (LE). Type I IFN serum levels have been shown to correlate with the disease activity in systemic LE and additionally play a proinflammatory role in the development of LE skin lesions. Recent studies demonstrated a close morphological association between the expression pattern of IFN-inducible chemokines (MxA, CXCL10) and typical histological features of cutaneous LE. These and other studies suggest that a complex network of IFN-associated cytokines, chemokines and adhesion molecules orchestrates and promotes tissue injury observed in LE skin.

Keywords

Skin Lupus CXCL9 CXCL10 CXCR3 

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Copyright information

© Springer-Verlag 2008

Authors and Affiliations

  • Joerg Wenzel
    • 1
  • Sabine Zahn
    • 1
  • Thomas Bieber
    • 1
  • Thomas Tüting
    • 1
  1. 1.Department of DermatologyUniversity of BonnBonnGermany

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