Archives of Dermatological Research

, Volume 301, Issue 1, pp 83–86 | Cite as

Type I interferon-associated cytotoxic inflammation in cutaneous lupus erythematosus

  • Joerg Wenzel
  • Sabine Zahn
  • Thomas Bieber
  • Thomas Tüting


Inappropriate activation of innate immune mechanisms, in particular of the type I interferon (IFN) system, is regarded to play an important role in the pathogenesis of lupus erythematosus (LE). Type I IFN serum levels have been shown to correlate with the disease activity in systemic LE and additionally play a proinflammatory role in the development of LE skin lesions. Recent studies demonstrated a close morphological association between the expression pattern of IFN-inducible chemokines (MxA, CXCL10) and typical histological features of cutaneous LE. These and other studies suggest that a complex network of IFN-associated cytokines, chemokines and adhesion molecules orchestrates and promotes tissue injury observed in LE skin.


Skin Lupus CXCL9 CXCL10 CXCR3 


Conflict of interest statement

The authors have no potential conflict of interest.


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Copyright information

© Springer-Verlag 2008

Authors and Affiliations

  • Joerg Wenzel
    • 1
  • Sabine Zahn
    • 1
  • Thomas Bieber
    • 1
  • Thomas Tüting
    • 1
  1. 1.Department of DermatologyUniversity of BonnBonnGermany

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