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Archives of Dermatological Research

, Volume 300, Issue 6, pp 325–329 | Cite as

LPS induces melanogenesis through p38 MAPK activation in human melanocytes

  • Joo Hee Ahn
  • Sun Hee Jin
  • Hee Young Kang
Short Communication

Abstract

We have observed that lipopolysaccharide (LPS) induces pigmentation in melanocytes and in this study have examined whether these responses are mediated by the p38 mitogen-activated protein kinase (MAPK) signaling pathway. LPS appears to stimulate the pigmentation of melanocytes and cultured skin. LPS was found to induce the expression of microphthalmia-associated transcription factor (MITF) and tyrosinase protein in cells. Stimulation of melanocytes with LPS led to time dependent phosphorylation of p38 MAPK. Furthermore, p38 MAPK functionally regulated the LPS-induced melanin formation in melanocytes; a p38 MAPK inhibitor, SB203580, almost completely attenuated the LPS-mediated up-regulation of melanin synthesis and induction of MITF and tyrosinase expression. These findings indicate that activation of p38 MAPK plays an important role in LPS-induced melanogenesis by up-regulating MITF and tyrosinase expression.

Keywords

Lipopolysaccharide (LPS) p38 mitogen-activated protein kinase Melanogenesis 

Notes

Acknowledgments

This work was supported by the Korean Science and Engineering Foundation (KOSEF). Grant funded by the Korean government (MOST) (R13-2003-019) and the “GRRC” Project of Gyeonggi Provincial Government, Republic of Korea.

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Copyright information

© Springer-Verlag 2008

Authors and Affiliations

  1. 1.Department of DermatologyAjou University School of MedicineSuwonSouth Korea

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