Parthenolide-depleted Feverfew (Tanacetum parthenium) protects skin from UV irradiation and external aggression
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The skin is under continual assault from a variety of damaging environmental factors such as ultraviolet irradiation and atmospheric pollutants, and as organisms age the cumulative damage exceeds the capacity of endogenous antioxidant defenses resulting in chronic inflammation and premature aging. Botanical extracts such as Feverfew containing naturally occurring antioxidants could replenish the depleted cutaneous stores and perhaps forestall these degenerative changes. A parthenolide-depleted extract of Feverfew (PD-Feverfew), which was free of sensitization potential, was found to possess free radical scavenging activity against a wide range of reactive oxygen species and with greater activity than Vitamin C. In vitro, PD-Feverfew restored cigarette smoke-mediated depletion of cellular thiols, attenuated the formation of UV-induced hydrogen peroxide and reduced pro-inflammatory cytokine release. In vivo, topical PD-Feverfew reduced UV-induced epidermal hyperplasia, DNA damage and apoptosis. In a clinical study PD-Feverfew treatment significantly reduced erythema versus placebo 24 h post-UV exposure. Through the ability to scavenge free radicals, preserve endogenous antioxidant levels, reduce DNA damage and induce DNA repair enzymes, which can help repair damaged DNA, parthenolide-depleted extract of Feverfew may protect skin from the numerous external aggressions encountered daily by the skin and reduce the damage to oxidatively challenged skin.
KeywordsFeverfew Flavonoids Oxidative stress Parthenolide Reactive oxygen species Inflammation
Reactive oxygen species
We would like to acknowledge Devon Grote, Dara Miller and Judy Pinto for their technical contributions, and Claude Saliou for the helpful discussions on antioxidants. We would like to thank Dr. Lynne B. Harrison for guidance and discussion on the clinical erythema studies.
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- 5.Babulak S, Rhein LD, Scala DD, Simion AF, Grove GL (1986) Quantitation of erythema in a soap chamber test using the Minolta chroma (reflectance) meter: comparison of instrumental results with visual assessments. J Soc Cosmet Chem 37:475–479Google Scholar
- 8.Bombardelli E, Morazzoni P (2001) Tanacetum parthenium extract and method of obtaining same. United States Patent US6,224,875 B1Google Scholar
- 9.Carnevali S, Petruzzelli S, Longoni B, Vanacore R, Barale R, Cipollini M et al (2003) Cigarette smoke extract induces oxidative stress and apoptosis in human lung fibroblasts. Am J Physiol 284:L955–L963Google Scholar
- 23.Kurtz E, Walczak VR (2005) Clinical safety review of topical emollient formulations containing parthenolide-free-extract of Feverfew. J Am Acad Dermatol 52:P87Google Scholar
- 41.Rusznak C, Mills PR, Devalia JL, Sapsford RJ, Davies RJ, Lozewicz S (2000) Effect of cigarette smoke on the permeability and IL-1beta and sICAM-1 release from cultured human bronchial epithelial cells of never-smokers, smokers, and patients with chronic obstructive pulmonary disease. Am J Respir Cell Mol Biol 23:530–536PubMedGoogle Scholar