Archives of Dermatological Research

, Volume 299, Issue 10, pp 499–505 | Cite as

Effect of oral intake of choline-stabilized orthosilicic acid on hair tensile strength and morphology in women with fine hair

  • R. R. Wickett
  • E. Kossmann
  • A. Barel
  • N. Demeester
  • P. Clarys
  • D. Vanden Berghe
  • M. CalommeEmail author
Original Paper


The appearance of hair plays an important role in people’s overall physical appearance and self-perception. Silicon (Si) has been suggested to have a role in the formation of connective tissue and is present at 1–10 ppm in hair. Choline-stabilized orthosilicic acid (“ch-OSA”) is a bioavailable form of silicon which was found to improve skin microrelief and skin mechanical properties in women with photoaged skin. The effect of ch-OSA on hair was investigated in a randomized, double blind, placebo-controlled study. Forty-eight women with fine hair were given 10 mg Si/day in the form of ch-OSA beadlets (n = 24) or a placebo (n = 24), orally for 9 months. Hair morphology and tensile properties were evaluated before and after treatment. Urinary silicon concentration increased significantly in the ch-OSA supplemented group but not in the placebo group. The elastic gradient decreased in both groups but the change was significantly smaller in the ch-OSA group (−4.52%) compared to placebo group (−11.9%). Break load changed significantly in the placebo group (−10.8%) but not in the ch-OSA supplemented group (−2.20%). Break stress and elastic modulus decreased in both groups but the change was smaller in the ch-OSA group. The cross sectional area increased significantly after 9 months compared to baseline in ch-OSA supplemented subjects but not in the placebo group. The change in urinary silicon excretion was significantly correlated with the change in cross sectional area. Oral intake of ch-OSA had a positive effect on tensile strength including elasticity and break load and resulted in thicker hair.


Hair Tensile strength Choline-stabilized orthosilicic acid Elasticity Break load 



ch-OSA was developed by Dirk Vanden Berghe for Bio Minerals n.v. This study was supported by a grant of Bio Minerals n.v. The Institute Dr. Schrader (Holzminden, Germany) was contracted as an independent research organization for the recruitment of volunteers and for the analysis of hair parameters.


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Copyright information

© Springer-Verlag 2007

Authors and Affiliations

  • R. R. Wickett
    • 1
  • E. Kossmann
    • 2
  • A. Barel
    • 3
  • N. Demeester
    • 4
  • P. Clarys
    • 3
  • D. Vanden Berghe
    • 4
  • M. Calomme
    • 4
    Email author
  1. 1.College of PharmacyUniversity of CincinnatiCincinnatiUSA
  2. 2.Practice for Dermatology and Cosmetic MedicineHolzmindenGermany
  3. 3.Faculty of Physical Education and PhysiotherapyVrije Universiteit BrusselBrusselsBelgium
  4. 4.Faculty of Pharmaceutical, Biomedical and Veterinary SciencesUniversity of AntwerpAntwerpBelgium

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