Archives of Dermatological Research

, Volume 299, Issue 8, pp 405–407

HLA-DRB1*0101 is associated with the genetic susceptibility to develop lichen planus in the Mexican Mestizo population

  • P. Luis-Montoya
  • J. K. Yamamoto-Furusho
  • E. Vega-Memije
  • A. Rodríguez-Carreón
  • J. A. Ruiz-Morales
  • G. Vargas-Alarcón
  • L. Domínguez-Soto
  • J. Granados
Short Communication

DOI: 10.1007/s00403-007-0769-2

Cite this article as:
Luis-Montoya, P., Yamamoto-Furusho, J.K., Vega-Memije, E. et al. Arch Dermatol Res (2007) 299: 405. doi:10.1007/s00403-007-0769-2

Abstract

The etiology of lichen planus (LP) is still unknown and previous studies have found an association between LP and HLA-DR1, DR2, DR3, DR9 and DR10 in different populations. The aim of this study was to analyze the distribution of the HLA-DRB1 alleles in Mexican Mestizo patients with LP. The aim of this study was to determine the gene frequency of HLA-DR locus in Mexican Mestizo patients with LP. We studied 20 patients with LP and 99 healthy Mexican Mestizo controls. HLA-DRB1 was performed by PCR-SSO reverse dot blot hybridization. High resolution HLA typing was performed by PCR-SSP. The HLA-DRB1*0101 allele was associated significantly in LP patients compared with healthy controls (pC = 0.0007, OR = 5.46, 95% CI = 1.86–16.06). HLA-DRB1*0101 is a marker for the development of LP in Mexican Mestizo population, yet another gene or HLA marker within MHC region may be the causatively associated gene.

Copyright information

© Springer-Verlag 2007

Authors and Affiliations

  • P. Luis-Montoya
    • 1
  • J. K. Yamamoto-Furusho
    • 2
  • E. Vega-Memije
    • 1
  • A. Rodríguez-Carreón
    • 1
  • J. A. Ruiz-Morales
    • 2
  • G. Vargas-Alarcón
    • 3
  • L. Domínguez-Soto
    • 1
  • J. Granados
    • 2
  1. 1.Department of DermatologyHospital General “Dr. Manuel Gea González”México D.F.Mexico
  2. 2.Immunology and Rheumatology DepartmentInstituto Nacional de Ciencias Médicas y Nutrición “Salvador Zubirán”Tlalpan D.F.Mexico
  3. 3.Department of PhysiologyInstituto Nacional de Cardiología “Ignacio Chávez”México D.F.Mexico

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