Archives of Dermatological Research

, Volume 298, Issue 10, pp 485–491

Systemic lupus erythematosus: a genetic epidemiology study of 695 patients from China

  • J. Wang
  • S. Yang
  • J. J. Chen
  • S. M. Zhou
  • S. M. He
  • Y. H. Liang
  • W. Meng
  • X. F. Yan
  • J. J. Liu
  • D. Q. Ye
  • X. J. Zhang
Original Paper

DOI: 10.1007/s00403-006-0719-4

Cite this article as:
Wang, J., Yang, S., Chen, J.J. et al. Arch Dermatol Res (2007) 298: 485. doi:10.1007/s00403-006-0719-4

Abstract

Our purpose was to explore potential genetic models for systemic lupus erythematosus (SLE) and analyze genetic epidemiologic characteristics of SLE in a Chinese population. Data for 695 patients with SLE were obtained by using a uniform questionnaire. Patients, clinical characteristics and their family history were analyzed using software. A complex segregation analysis was conducted to propose potential genetic models for SLE. The mean ± SD age of onset were 30.2 ± 10.5 years and mean time to progression to SLE was 32.5 ± 44.4 months. The most frequent initial manifestations were malar rash (61.3%). During the evolution of the disease, the main clinical features were arthritis in 73.6% of our patients, followed by malar rash (68.1%), and renal involvement (56.7%). As the first symptom, the late-onset group (onset of disease beyond the age of 50 years) less often showed malar rash (45% vs. 63.4% in the early-onset group; p = 0.001). There were no significant differences in the other cumulative clinical symptoms between late-onset and early-onset group, except for a lower prevalence of malar rash, photosensitivity and alopecia and a higher prevalence of mucosal ulcers in the late-onset group. A positive family history of SLE was obtained in 50 patients (7.2%). There were no statistical differences in clinical characteristics between familial SLE and sporadic SLE patients. The heritability of SLE was 43.6%, the genetic model of SLE could be polygenetic model and major gene mode is the best fitted one. SLE could be a multifactorial disease with polygenetic model.

Keywords

China Genetic epidemiology Systemic lupus erythematosus 

Copyright information

© Springer-Verlag 2006

Authors and Affiliations

  • J. Wang
    • 1
    • 2
  • S. Yang
    • 1
    • 2
  • J. J. Chen
    • 1
    • 2
  • S. M. Zhou
    • 1
    • 2
  • S. M. He
    • 1
    • 2
  • Y. H. Liang
    • 1
    • 2
  • W. Meng
    • 3
  • X. F. Yan
    • 3
  • J. J. Liu
    • 1
    • 2
    • 4
  • D. Q. Ye
    • 5
  • X. J. Zhang
    • 1
    • 2
  1. 1.Institute of Dermatology and Department of Dermatology at First HospitalAnhui Medical UniversityHefeiPeople’s Republic of China
  2. 2.Key Laboratory of Genome Research of Anhui ProvinceHefeiPeople’s Republic of China
  3. 3.Department of EpidemiologyMedical college of FuDan universityShanghaiPeople’s Republic of China
  4. 4.Genome Institute of SingaporeSingaporeSingapore
  5. 5.Department of EpidemiologyAnhui Medical UniversityHefeiPeople’s Republic of China

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