Archives of Dermatological Research

, Volume 298, Issue 4, pp 147–152 | Cite as

A comparative study of oxidant–antioxidant status in stable and active vitiligo patients

  • Dammak InesEmail author
  • Boudaya Sonia
  • Ben Mansour Riadh
  • El Gaied Amel
  • Marrekchi Slaheddine
  • Turki Hamida
  • Attia Hamadi
  • Hentati Basma
Hot Clinical Study


The pathogenetic mechanisms in vitiligo have not been completely clarified. One of the major hypotheses in the pathogenesis of vitiligo is the oxidative stress hypothesis. The active or stable phase of vitiligo is defined on the basis of the progression or appearance of new lesions in the last 3 months and the absence of new lesions or their progression in the last 6 months, respectively. Eighteen patients with active vitiligo, 18 patients with stable vitiligo, and 40 controls were included in this study. We examined serum levels of malondialdehyde, selenium, vitamin E and A, and the erythrocyte activities of glutathione peroxidase, superoxide dismutase, and catalase. Our results revealed a significantly higher level of serum malondialdehyde, selenium in patients with active disease compared with the controls. Significant higher increase in erythrocytes superoxide dismutase activities was observed in active vitiligo group, erythrocyte glutathione peroxidase activity was decreased significantly in active disease, whereas erythrocyte catalase activity and plasma vitamin E and A levels were not different in vitiligo patients as compared with controls. Our study shows that oxidative stress is involved in the pathophysiology of both active and stable vitiligo but increased imbalance of antioxidants was observed in the blood of active vitiligo patients.


Active vitiligo Stable vitiligo Oxidative stress 



We thank Dr Laporte François for his help in the serum selenium determination. (Dr. Laporte François. Laboratoire de Biologie du stress oxydant, UFR des Sciences Pharmaceutiques et Biologiques, Grenoble, France).

Prior to initiation of the study, each subject was informed about the purpose of the study and gives us an informed consent.


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Copyright information

© Springer-Verlag 2006

Authors and Affiliations

  • Dammak Ines
    • 1
    Email author
  • Boudaya Sonia
    • 2
  • Ben Mansour Riadh
    • 5
  • El Gaied Amel
    • 3
  • Marrekchi Slaheddine
    • 2
  • Turki Hamida
    • 2
  • Attia Hamadi
    • 6
  • Hentati Basma
    • 4
  1. 1.Institut supérieur de biotechnologie de SfaxSfaxTunisia
  2. 2.Servie de DermatologieCentre Hospitalo-UniversitaireSfaxTunisia
  3. 3.Technicienne à l’institut supérieur de biotechnologie de SfaxSfaxTunisia
  4. 4.Directrice de l’institut supérieur de biotechnologie de SfaxSfaxTunisia
  5. 5.Doctorant a l’institut superieur de Biotechnologie de SfaxSfaxTunisia
  6. 6.Chef de l’unité de recherche: Pathologies Humaines et stress oxydatif à l’institut superieur de Biotechnologie de SfaxSfaxTunisia

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