Archives of Dermatological Research

, Volume 297, Issue 2, pp 94–98 | Cite as

An insertion/deletion polymorphism in the gene encoding angiotensin converting enzyme is not associated with generalised vitiligo in an English population

  • Samia Akhtar
  • Nikos G. Gavalas
  • David J. Gawkrodger
  • Philip F. Watson
  • Anthony P. Weetman
  • E. Helen Kemp
Short Communication

Abstract

Vitiligo is an acquired hypomelanotic skin disorder characterised by circumscribed depigmented macules resulting from the loss of functional melanocytes from the cutaneous epidermis and autoimmunity has been suggested to play a role in the pathogenesis of the disease. Recently, an insertion/deletion (I/D) polymorphism of a 287-base pair repetitive sequence in intron 16 of the angiotensin converting enzyme (ACE) gene has been associated with autoimmune disease and with the development of vitiligo. In this study, the distribution of ACE gene I/D genotypes was investigated in a population of 106 English patients with generalised (non-segmental) vitiligo and 174 ethnically matched healthy controls using a restriction fragment length polymorphism-polymerase chain reaction genotyping method. No significant difference in the frequencies of II, ID and DD genotypes was detected between vitiligo patients and control subjects (P=0.35). The same result was evident for the genotype distribution in vitiligo patients with an autoimmune disease and for those without when compared with controls (P=0.33 and P=0.53, respectively). In addition, the results indicated that the D allele was not significantly over-represented in the group of patients with vitiligo compared with controls (P=0.42) and that this was also the case for patients with and without associated autoimmunity (P=0.40 and P=0.62, respectively).

Keywords

Angiotensin converting enzyme Autoimmunity Genetic susceptibility Melanocyte Gene polymorphism Vitiligo 

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Copyright information

© Springer-Verlag 2005

Authors and Affiliations

  • Samia Akhtar
    • 1
  • Nikos G. Gavalas
    • 1
  • David J. Gawkrodger
    • 2
  • Philip F. Watson
    • 1
  • Anthony P. Weetman
    • 1
  • E. Helen Kemp
    • 1
  1. 1.Division of Clinical Sciences (North)University of Sheffield, Northern General HospitalSheffieldUK
  2. 2.Department of DermatologyRoyal Hallamshire HospitalSheffieldUK

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