Advertisement

Archives of Dermatological Research

, Volume 296, Issue 5, pp 240–241 | Cite as

Why is polymorphous light eruption so common in young women?

  • F. Aubin
Letter to the Editors

Abstract

Despite the fact that polymorphous light eruption (PLE) is the most common photodermatosis, affecting 15% of healthy people in the UK, its pathogeny remains unclear. The condition is more frequent in females and begins often in young adults and in mid-adult life. The mechanism of PLE is under active research as shown by recent results, and it is hypothesized that in PLE patients, there is a partial failure of ultraviolet radiation-induced immunosuppression, causing an abnormal response to autologous antigens generated by ultraviolet radiation (UVR). The recent demonstration that the female hormone, 17β-estradiol prevents UVR-induced suppression of the contact hypersensitivity response caused by the release of immunosuppressive cytokines (IL-10) from keratinocytes might thus explain why the risk of PLE is higher in females than in males and why the risk decreases in women after the menopause.

Keywords

Immunosuppressive Cytokine Female Hormone Partial Failure Minimal Erythema Dose Polymorphous Light Eruption 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

References

  1. 1.
    Hiramoto K, Tanaka H, Yanagihara N, Sato EF, Inoue M (2004) Effect of 17beta-estradiol on immunosuppression induced by ultraviolet B irradiation. Arch Dermatol Res 295:307–311CrossRefPubMedGoogle Scholar
  2. 2.
    Epstein S (1942) Studies in abnormal human sensitivity to light. IV. Photoallergic concept of prurigo aestivalis. J Invest Dermatol 25:289–298Google Scholar
  3. 3.
    Palmer RA, Friedmann PS (2004) Ultraviolet radiation causes less immunosuppression in patients with polymorphic light eruption than in controls. J Invest Dermatol 122:291–294PubMedGoogle Scholar
  4. 4.
    van de Pas CB, Kelly DA, Seed PT, Young AR, Hawk JL, Walker SL (2004) Ultraviolet-radiation-induced erythema and suppression of contact hypersensitivity responses in patients with polymorphic light eruption. J Invest Dermatol 122:295–299PubMedGoogle Scholar
  5. 5.
    Pao C, Norris PG, Corbett M, Hawk JL (1994) Polymorphic light eruption: prevalence in Australia and England. Br J Dermatol 130:2–4Google Scholar
  6. 6.
    Aubin F (2003) Mechanisms involved in ultraviolet light-induced immunosuppression. Eur J Dermatol 13:515–523PubMedGoogle Scholar
  7. 7.
    Kolgen W, Van Weelden H, Den Hengst S, Guikers KL, Kiekens RC, Knol EF, Bruijnzeel-Koomen CA, Van Vloten WA, de Gruijl FR (1999) CD11b+ cells and ultraviolet-B-resistant CD1a+ cells in skin of patients with polymorphous light eruption. J Invest Dermatol 113:4–10CrossRefPubMedGoogle Scholar
  8. 8.
    Schornagel IJ, Sigurdsson V, Nijhuis EH, Bruijnzeel-Koomen CA, Knol EF (2004) Decreased neutrophil skin infiltration after UVB exposure in patients with polymorphous light eruption. J Invest Dermatol 123:202–206CrossRefPubMedGoogle Scholar
  9. 9.
    Norris PG, Morris J, McGibbon DM, Chu AC, Hawk JL (1989) Polymorphic light eruption: an immunopathological study of evolving lesions. Br J Dermatol 120:173–183PubMedGoogle Scholar
  10. 10.
    Kölgen W (2003) Unravelling the pathogenesis of polymorphous light eruption. A comparative study in patients with polymorphous light eruption and healthy individuals. PhD Thesis, University of UtrechtGoogle Scholar
  11. 11.
    Gonzalez-Amaro R, Baranda L, Salazar-Gonzalez JF, Abud-Mendoza C, Moncada B (1991) Immune sensitization against epidermal antigens in polymorphous light eruption. J Am Acad Dermatol 24:70–73PubMedGoogle Scholar

Copyright information

© Springer-Verlag 2004

Authors and Affiliations

  1. 1.Department of DermatologyUniversity HospitalBesançonFrance

Personalised recommendations