Archives of Dermatological Research

, Volume 294, Issue 8, pp 383–385 | Cite as

Enhancement effects of (R) and (S) enantiomers and the racemate of a model enhancer on permeation of theophylline through human skin

  • Katerina Vávrová
  • Alexandr Hrabálek
  • Pavel Doležal
Short Communication

Abstract.

The conformation of a permeation enhancer, given their mechanism of action, could influence its enhancing properties, since the stratum corneum components form essentially a chiral environment. The racemate and both enantiomers of 6-aminohexanoic acid 2-octylester as model enhancers with one chiral center were synthesized and their ability to enhance in vitro theophylline permeation through human skin was tested. The MTMT concept could not be applied in this study (the melting points of the substances were lower than 20ºC) and we observed no significant difference in enhancement ratios (ERs) of racemic 6-aminohexanoic acid 2-octylester and that of each enantiomer. However, differences in permeation rates between enantiomers and their racemates do not have to be related to stereoselective interactions, since they may also be explained by differences in physicochemical properties. The study also showed that there was no difference in the permeation enhancement ability between the (R)-(–) and (S)-(+) isomers of 6-aminohexanoic acid 2-octylester (the ERs were 2.72±0.42 and 2.79±0.60 for (R) and (S) enantiomers, respectively), suggesting that the enhancing properties of the compounds are not dependent on their spatial arrangement. Although stereoselective interactions between an enhancer and stratum corneum components may exist, they seem not to be important for the enhancer action.

Stratum corneum Chirality 6-Aminohexanoic acid 2-octylester 

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Copyright information

© Springer-Verlag 2002

Authors and Affiliations

  • Katerina Vávrová
    • 1
  • Alexandr Hrabálek
    • 1
  • Pavel Doležal
    • 1
  1. 1.Charles University in Prague, Faculty of Pharmacy in Hradec Králové, Heyrovského 1203, 50005 Hradec Králové, Czech Republic

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