Archives of Orthopaedic and Trauma Surgery

, Volume 132, Issue 8, pp 1147–1152 | Cite as

Fibrin sealants in orthopaedic surgery: practical experiences derived from use of QUIXIL® in total knee arthroplasty

  • Torsten Kluba
  • Katrin Fiedler
  • Beate Kunze
  • Ingmar Ipach
  • Andreas Suckel
Knee Arthroplasty



Total knee arthroplasty is associated with a significant postoperative blood loss even without any form of perioperative anticoagulation.


The potential role of QUIXIL®, a fibrin sealant used in orthopaedic surgery to control blood loss and avoid blood transfusions in patients undergoing total knee arthroplasty was evaluated in a prospective randomized trial with twenty-four patients diagnosed with primary osteoarthritis of the knee.


Results showed that application of 2 ml QUIXIL® adds costs to treatment without reducing the number of transfused red blood cell counts and postoperative haemoglobin loss. However, significant lower levels of postoperative fluid loss (P = 0.026) was detected in QUIXIL® treated patients.


Regarding cost effectiveness and benefit no indication for the use of 2 ml QUIXIL® fibrin sealant in standard knee arthroplasty could be proofed statistically.


Knee arthroplasty Fibrin sealants Blood loss 


Conflict of interest

The authors declare that there has been no conflict of interest.


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Copyright information

© Springer-Verlag 2012

Authors and Affiliations

  • Torsten Kluba
    • 1
  • Katrin Fiedler
    • 1
  • Beate Kunze
    • 1
  • Ingmar Ipach
    • 1
  • Andreas Suckel
    • 2
  1. 1.Department of OrthopaedicsUniversity TübingenTübingenGermany
  2. 2.Department of Orthopaedic and Trauma SurgeryKatharinenhospitalStuttgartGermany

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