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Archives of Orthopaedic and Trauma Surgery

, Volume 132, Issue 8, pp 1147–1152 | Cite as

Fibrin sealants in orthopaedic surgery: practical experiences derived from use of QUIXIL® in total knee arthroplasty

  • Torsten Kluba
  • Katrin Fiedler
  • Beate Kunze
  • Ingmar Ipach
  • Andreas Suckel
Knee Arthroplasty

Abstract

Background

Total knee arthroplasty is associated with a significant postoperative blood loss even without any form of perioperative anticoagulation.

Methods

The potential role of QUIXIL®, a fibrin sealant used in orthopaedic surgery to control blood loss and avoid blood transfusions in patients undergoing total knee arthroplasty was evaluated in a prospective randomized trial with twenty-four patients diagnosed with primary osteoarthritis of the knee.

Results

Results showed that application of 2 ml QUIXIL® adds costs to treatment without reducing the number of transfused red blood cell counts and postoperative haemoglobin loss. However, significant lower levels of postoperative fluid loss (P = 0.026) was detected in QUIXIL® treated patients.

Conclusion

Regarding cost effectiveness and benefit no indication for the use of 2 ml QUIXIL® fibrin sealant in standard knee arthroplasty could be proofed statistically.

Keywords

Knee arthroplasty Fibrin sealants Blood loss 

Notes

Conflict of interest

The authors declare that there has been no conflict of interest.

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Copyright information

© Springer-Verlag 2012

Authors and Affiliations

  • Torsten Kluba
    • 1
  • Katrin Fiedler
    • 1
  • Beate Kunze
    • 1
  • Ingmar Ipach
    • 1
  • Andreas Suckel
    • 2
  1. 1.Department of OrthopaedicsUniversity TübingenTübingenGermany
  2. 2.Department of Orthopaedic and Trauma SurgeryKatharinenhospitalStuttgartGermany

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