Diagnostic and therapeutic problems of giant cell tumor in the proximal femur
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Abstract
Primaly giant cell tumor of bone (GCT) in the proximal femur is relatively rare, and can prove difficult to diagnose, and can require therapeutic methods. Subjects comprised 10 patients (8 males, 2 females). Mean patient age was 27.5 years, and mean follow-up was 89.9 months. Tumors in the present study were limited to H1 and H2 according to the International Society of Limb Salvage (ISOLS) system. All patients received surgical treatment only. Second surgery after preoperative open biopsy was performed for two patients, while the remaining eight patients received excisional biopsy to determine treatment methods using rapid intraoperative pathological examination of frozen sections. The mean functional score was 28.2 out of 30 (93.9%). Local recurrence was observed in two patients. The long-term follow-up reveals that one of the important problem is pre-operative diagnosis. Excisional biopsy is effective for surgery of GCT in the proximal femur.
Keywords
Giant cell tumor Proximal femur Bone tumor Femoral neckReferences
- 1.Adler CP (1995) Solid aneurysmal bone cyst with pathological bone fracture. Skeletal Radiol 24:214–216PubMedCrossRefGoogle Scholar
- 2.Aoki J, Tanikawa H, Ishii K et al (1996) MR findings indicative of hemosiderin in giant-cell tumor of bone: frequency, cause, and diagnostic significance. Am J Roentgenol 166:145–148Google Scholar
- 3.De Silva MVC, Reid R (2003) Chondroblastoma: varied histologic appearance, potential diagnostic pitfalls, and clinicopathologic features associated with local recurrence. Ann Diagn Pathol 7:205–213PubMedCrossRefGoogle Scholar
- 4.Dowdy PA, Griffin AM, White LM et al (1998) Bone sarcoma diagnosed at the time of reconstructive hip surgery. Can J Surg 41:273–282PubMedGoogle Scholar
- 5.Enneking WF, Dunham W, Gebhardt MC et al (1993) A system for the functional evaluation of reconstructive procedures after surgical treatment of tumors of the musculoskeletal system. Clin Orthop 286:241–246PubMedGoogle Scholar
- 6.Fanning CV, Sneige NS, Carrasco CH et al (1990) Fine needle aspiration cytology of chondroblastoma of bone. Cancer 65:1847–18633PubMedCrossRefGoogle Scholar
- 7.Irwin RB, Sauchak JA, O’Brien MP (1998) Tumors of the proximal femur: case examples and literature review. Orthopedics 21:182–189PubMedGoogle Scholar
- 8.Koh JS, Chung JH, Lee SY et al (2001) Chondroblastoma of the proximal femur with myxoid degeneration mistaken for chondromyxoid fibroma in a young adults. A case report. Acta Cytol 45:254–258PubMedGoogle Scholar
- 9.Komiya S, Inoue A (1993) Cementation in the treatment of giant cell tumor of bone. Arch Orthop Trauma Surg 112:51–55PubMedCrossRefGoogle Scholar
- 10.Kulkarni SS, Dogra AS, Bhosale PB (1996) Total hip arthroplasty for giant cell tuour. J Postgrad Med 42:82–84PubMedGoogle Scholar
- 11.Kumta SM, Leung PC, Yip K et al (1998) Vascularized bone grafts in the treatment of juxta-articular giant-cell tumors of the bone. J Reconstr Microsurg 14:185–190PubMedCrossRefGoogle Scholar
- 12.Leung PC, Chow YYN (1984) Reconstruction of proximal femoral defects with a vascular-pedicled graft. J Bone Joint Surg (Br) 66:32–37Google Scholar
- 13.Malawer MM, Dunham W (1991) Cryosurgery and acrylic cementation as surgical adjuncts in the treatment of aggressive (benign) bone tumors. Analysis of 25 patients below the age of 21. Clin Orthop 262:42–57PubMedGoogle Scholar
- 14.Murphey MD, Nomikos GC, Flemming DJ et al (2001) From the archives of AFIP. Imaging of giant cell tumor and giant cell reparative granuloma of bone: radiologic–pathologic correlation. Radiographics 21:1283–1309PubMedGoogle Scholar
- 15.Oda Y, Miura H, Tsuneyoshi M et al (1998) Giant cell tumor of bone: oncological and functional results of long-term follow-up. Jpn J Clin Oncol 28:323–328PubMedCrossRefGoogle Scholar
- 16.O’Donnell RJ, Springfield DS, Motwani HK et al (1994) Recurrence of giant-cell tumors of the long bones after curettage and packing with cement. J Bone Joint Surg (Am) 76:1827–1833Google Scholar
- 17.Ogose A, Hotta T, Hatano H et al (2002) Histological examination of beta-tricalcium phosphate graft in human femur. J Biomed Mater Res 63:601–604PubMedCrossRefGoogle Scholar
- 18.Schajowicz F (1981) Giant cell tumor (osteocrastoma). In: Shajowicz F (ed) Tumours and tumour like lesions of bone and joints. Springer, New York, 205 ppGoogle Scholar
- 19.Sim E, Lang S (1997) Joint salvaging surgery for an extensive giant cell tumor of the proximal femur complicated by a transcervical fracture. Arch Orthop Trauma Surg 116:431–434PubMedGoogle Scholar
- 20.Temple HT, Kuklo TR, Lehman RA Jr et al (2000) Segmental limb reconstruction after tumor resection. Am J Orthop 29:524–529PubMedCrossRefGoogle Scholar
- 21.Wai EK, Davis AM, Griffin A et al (2001) Pathologic fractures of the proximal femur secondary to benign bone tumors. Clin Orthop 393:279–286PubMedCrossRefGoogle Scholar
- 22.Yip KMH, Leung PC, Kumta SM (1996) Giant cell tumor of bone. Clin Orthop 323:60–64PubMedCrossRefGoogle Scholar
- 23.Zwart HJ, Taminiau AH, Schimmel JW et al (1994) Kottz modular femur and tibia replacement. 28 tumor cases followed for 3(1–8) years. Acta Orthop Scand 65:315–318 PubMedCrossRefGoogle Scholar