Acta Neuropathologica

, Volume 100, Issue 1, pp 1–12

Senile dementia associated with amyloid β protein angiopathy and tau perivascular pathology but not neuritic plaques in patients homozygous for the APOE-ε4 allele

  • Rubén Vidal
  • Miguel Calero
  • Pedro Piccardo
  • Martin R. Farlow
  • Frederick W. Unverzagt
  • Enrique Méndez
  • Adolfo Jiménez-Huete
  • Ronald Beavis
  • Gloria Gallo
  • Estrella Gomez-Tortosa
  • Jorge Ghiso
  • Bradley T. Hyman
  • Blas Frangione
  • B. Ghetti
Regular Paper

DOI: 10.1007/s004010051186

Cite this article as:
Vidal, R., Calero, M., Piccardo, P. et al. Acta Neuropathol (2000) 100: 1. doi:10.1007/s004010051186
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Abstract

Amyloid β protein deposition in cortical and leptomeningeal vessels, causing the most common type of cerebral amyloid angiopathy, is found in sporadic and familial Alzheimer’s disease (AD) and is the principal feature in the hereditary cerebral hemorrhage with amyloidosis, Dutch type. The presence of the Apolipoprotein E (APOE)-ɛ4 allele has been implicated as a risk factor for AD and the development of cerebral amyloid angiopathy in AD. We report clinical, pathological and biochemical studies on two APOE-ɛ4 homozygous subjects, who had senile dementia and whose main neuropathological feature was a severe and diffuse amyloid angiopathy associated with perivascular tau neurofibrillary pathology. Amyloid β protein and ApoE immunoreactivity were observed in leptomeningeal vessels as well as in medium-sized and small vessels and capillaries in the parenchyma of the neocortex, hippocampus, thalamus, cerebellum, midbrain, pons, and medulla. The predominant peptide form of amyloid β protein was that terminating at residue Val40, as determined by immunohistochemistry, amino acid sequence and mass spectrometry analysis. A crown of tau-immunopositive cell processes was consistently present around blood vessels. DNA sequence analysis of the Amyloid Precursor Protein gene and Presenilin-1 (PS-1) gene revealed no mutations. In these APOE-ɛ4 homozygous patients, the pathological process differed from that typically seen in AD in that they showed a heavy burden of perivascular tau-immunopositive cell processes associated with severe amyloid β protein angiopathy, neurofibrillary tangles, some cortical Lewy bodies and an absence of neuritic plaques. These cases emphasize the concept that tau deposits may be pathogenetically related to amyloid β protein deposition.

Key words Alzheimer’s disease Cerebral amyloid angiopathy Amyloid β protein Neurofibrillary tangles Senile plaques 

Copyright information

© Springer-Verlag Berlin Heidelberg 2000

Authors and Affiliations

  • Rubén Vidal
    • 1
  • Miguel Calero
    • 1
  • Pedro Piccardo
    • 2
  • Martin R. Farlow
    • 4
  • Frederick W. Unverzagt
    • 5
  • Enrique Méndez
    • 6
  • Adolfo Jiménez-Huete
    • 1
  • Ronald Beavis
    • 3
  • Gloria Gallo
    • 1
  • Estrella Gomez-Tortosa
    • 7
  • Jorge Ghiso
    • 1
  • Bradley T. Hyman
    • 7
  • Blas Frangione
    • 1
  • B. Ghetti
    • 2
  1. 1.Department of Pathology, New York University School of Medicine, New York, NY 10016, USAUS
  2. 2.Department of Pathology and Laboratory Medicine, Indiana University School of Medicine, 635 Barnhill Drive, Indianapolis, IN 46202, USA e-mail: bghetti@iupui.eduIN
  3. 3.Department of Pharmacology, New York University School of Medicine, New York, NY 10016, USAUS
  4. 4.Department of Neurology, Indiana University School of Medicine, Indiananpolis, IN 46202, USAIN
  5. 5.Department of Psychiatry, Indiana University School of Medicine, Indianapolis, IN 46202, USAIN
  6. 6.Unidad de Análisis Estructural de Proteínas, Centro Nacional de Biotecnología, Madrid, SpainES
  7. 7.Alzheimer Reasearch Unit, Massachusetts General Hospital, Charleston, MA 02129, USAUS

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