Acta Neuropathologica

, Volume 96, Issue 5, pp 439–444

NACP/α-synuclein immunoreactivity in fibrillary components of neuronal and oligodendroglial cytoplasmic inclusions in the pontine nuclei in multiple system atrophy

  • K. Arima
  • Kenji Uéda
  • Nobuhiko Sunohara
  • Kenji Arakawa
  • Shigeo Hirai
  • Minako Nakamura
  • Haruko Tonozuka-Uehara
  • Mitsuru Kawai
Express communication

Abstract

We examined neuronal cytoplasmic inclusions (NCIs) and oligodendrocytic glial cytoplasmic inclusions (GCIs) in the pontine nuclei in multiple system atrophy (MSA) using antibodies against the non-amyloid β component of Alzheimer’s disease amyloid precursor protein (NACP/α-synuclein). Our immunohistochemical study revealed that anti-NACP antibodies labeled both NCIs and GCIs. Immunoelectron microscopy showed that positive reaction products were localized on the 15- to 30-nm-thick filamentous components of NCIs and GCIs. The present study demonstrates that NACP is associated with cytoplasmic inclusions of MSA, and suggests a role of NACP in abnormal filament aggregation in neuronal degeneration.

Key words NACP Synuclein Multiple system atrophy Neuronal cytoplasmic inclusions Glial cytoplasmic inclusions 

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Copyright information

© Springer-Verlag Berlin Heidelberg 1998

Authors and Affiliations

  • K. Arima
    • 1
  • Kenji Uéda
    • 2
  • Nobuhiko Sunohara
    • 4
  • Kenji Arakawa
    • 4
  • Shigeo Hirai
    • 3
  • Minako Nakamura
    • 1
  • Haruko Tonozuka-Uehara
    • 2
  • Mitsuru Kawai
    • 3
  1. 1.Department of Ultrastructure and Histochemistry, Tokyo Institute of Psychiatry, 2-1-8 Kamikitazawa, Setagaya-ku, Tokyo 156-8585, Japan e-mail: arima@prit.go.jp, Tel.: +81-3-3304-5701, Fax: +81-3-3329-8035JP
  2. 2.Department of Neurochemistry, Tokyo Institute of Psychiatry, 2-1-8 Kamikitazawa, Setagaya-ku, Tokyo 156-8585, JapanJP
  3. 3.Department of Laboratory Medicine, National Center Hospital for Mental, Nervous, and Muscular Disorders, National Center of Neurology and Psychiatry (NCNP), Kodaira, Tokyo 187-8551, JapanJP
  4. 4.Department of Neurology, National Center Hospital for Mental, Nervous, and Muscular Disorders, NCNP, Kodaira, Tokyo 187-8551, JapanJP
  5. 5.Department of Psychiatry, National Center Hospital for Mental, Nervous, and Muscular Disorders, NCNP, Kodaira, Tokyo 187-8551, JapanJP

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