Acta Neuropathologica

, Volume 96, Issue 1, pp 97–101

Late-onset progressive spinocerebellar degeneration in Brittany Spaniel dogs

  • R. J. Higgins
  • Richard A. LeCouteur
  • Joe N. Kornegay
  • Joan R. Coates
Case Report

DOI: 10.1007/s004010050865

Cite this article as:
Higgins, R., LeCouteur, R., Kornegay, J. et al. Acta Neuropathol (1998) 96: 97. doi:10.1007/s004010050865

Abstract

Eight Brittany Spaniel dogs, seven females and one male, between 7 and 14 years old presented with clinical neurological signs of spinocerebellar disease of about 6 months to 4 years duration. Clinically the dogs had a dramatic forward “saluting” movement of the thoracic limbs, hypermetria of the pelvic limbs, cerebellar ataxia and intention tremors. Terminally, dogs crawled in a crouched thoracic posture with neck extension. Lesions were confined to cerebellum, medulla oblongata and spinal cord. The most severe lesion was diffuse Purkinje cell loss with massive neurofilament accumulation in degenerating cells. There was some bilateral neuronal degeneration in the dorsal horns of the spinal cord and in the gracilis and cuneate nuclei. There was bilateral sporadic axonal degeneration in the dorsal columns and lateral and ventromedial areas of the spinal cord. The etiology of this syndrome was not determined.

Key words Brittany Spaniel dog Immunocytochemistry Purkinje cell Spinocerebellar degeneration Ultrastructure 

Copyright information

© Springer-Verlag Berlin Heidelberg 1998

Authors and Affiliations

  • R. J. Higgins
    • 1
  • Richard A. LeCouteur
    • 2
  • Joe N. Kornegay
    • 3
  • Joan R. Coates
    • 4
  1. 1.Department of Pathology, Microbiology and Immunology, School of Veterinary Medicine, University of California, Davis, Davis, CA 95616, USA Tel.: 1-916-752-1183; Fax: 1-916-752-3349, e-mail: rjhiggins@ucdavis.eduUS
  2. 2.Department of Surgical and Radiological Sciences, School of Veterinary Medicine, University of California at Davis, Davis, CA 95616, USAUS
  3. 3.Department of Clinical Sciences, College of Veterinary Medicine, Columbia, MO 66205, USAUS
  4. 4.Department of Small Animal Medicine, College of Veterinary Medicine, Athens, GA 30605, USAUS

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