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Acta Neuropathologica

, Volume 92, Issue 4, pp 358–361 | Cite as

The main HTLV-I-harboring cells in the muscles of viral carriers with polymyositis are not macrophages but CD4+ lymphocytes

  • I. Higuchi
  • K. Hashimoto
  • E. Matsuoka
  • R. Rosales
  • M. Nakagawa
  • K. Arimura
  • S. Izumo
  • M. Osame
Regular paper

Abstract

We have analyzed muscle biopsy specimens from polymyositis patients who are also positive for human T cell lymphotropic virus type I (HTLV-I) using both immunohistochemistry for surface antigens of lymphocytes and macrophages and in situ polymerase chain reaction for HTLV-I proviral DNA on the same sections. We found HTLV-I in CD4+ cells but not in macrophages. This finding suggests that most of the HTLV-I-containing CD4+ cells are not macrophages but lymphocytes.

Key words In situ polymerase chain reaction Immunohistochemistry Human T cell lymphotropic virus type I Proviral DNA Polymyositis 

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Copyright information

© Springer-Verlag Berlin Heidelberg 1996

Authors and Affiliations

  • I. Higuchi
    • 1
  • K. Hashimoto
    • 1
  • E. Matsuoka
    • 1
  • R. Rosales
    • 1
  • M. Nakagawa
    • 1
  • K. Arimura
    • 1
  • S. Izumo
    • 2
  • M. Osame
    • 1
  1. 1.Third Department of Internal Medicine, Faculty of Medicine, Kagoshima University, 8-35-1 Sakuragaoka, Kagoshima 890, Japan Tel.: 81-99-275-5332; Fax: 81-99-265-7164; e-mail: ihiguchi@med6.kufm.kagoshima-u.ac.jpJP
  2. 2.Molecular Pathology and Genetic Epidemiology, Center for Chronic Viral Diseases, Faculty of Medicine, Kagoshima University, Kagoshima, JapanJP

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