Acta Neuropathologica

, Volume 92, Issue 2, pp 197–201 | Cite as

Development of Alzheimer-related neurofibrillary changes in the neocortex inversely recapitulates cortical myelogenesis

  • H. Braak
  • E. Braak
Short original communication

Abstract

The pattern of neurofibrillary changes which gradually develops in the course of Alzheimer’s disease bears a striking resemblance to the inverse sequence of cortical myelination. Factors released by oligodendrocytes exert a strong influence upon nerve cells and suppress disordered neuritic outgrowth. It is suggested that the lack of such factors due to premature dysfunction of oligodendrocytes leads to alterations of the neuronal cytoskeleton and eventually to the appearance of Alzheimer-type neurofibrillary changes.

Key words Oligodendrocytes Myelination Alzheimer’s disease Neurofibrillary tangles Neuropil threads 

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

Copyright information

© Springer-Verlag Berlin Heidelberg 1996

Authors and Affiliations

  • H. Braak
    • 1
  • E. Braak
    • 1
  1. 1.Department of Anatomy, J. W. Goethe University, Theodor Stern Kai 7, D-60590 Frankfurt/Main, Germany Tel.: 49-69-6301-6900; Fax: 49-69-6301-6425DE

Personalised recommendations