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Acta Neuropathologica

, Volume 91, Issue 4, pp 427–431 | Cite as

Progressive supranuclear palsy: a clinicopathological study of 21 cases

  • M. Verny
  • K. A. Jellinger
  • J.-J. Hauw
  • C. Bancher
  • I. Litvan
  • Y. Agid
Regular paper

Abstract

The symptoms and signs used to diagnose progressive supranuclear palsy (PSP) should be easily identifiable by neuropathologists and neurologists as well as by movement disorder experts. The presence, at the time of death, of symptoms and signs that are used in published clinical criteria for the diagnosis of this disorder was searched for in 21 pathologically confirmed typical PSP cases. The following items, present in at least 80% of pathologically confirmed cases, can be considered as the most accurate clinical data for the diagnosis of PSP: nonfamilial parkinsonism, not improved by l-dopa therapy, with vertical voluntary gaze palsy; postural instability and falls; pseudobulbar palsy and dementia with frontal lobe-like syndrome; and a progressive course of less than 10 years. The definite diagnosis of PSP must be clinicopathological, and these minimal clinical data may be used for this purpose.

Key words Progressive supranuclear palsy Symptoms Diagnostic criteria 

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Copyright information

© Springer-Verlag Berlin Heidelberg 1996

Authors and Affiliations

  • M. Verny
    • 1
  • K. A. Jellinger
    • 3
  • J.-J. Hauw
    • 2
  • C. Bancher
    • 3
  • I. Litvan
    • 4
  • Y. Agid
    • 5
  1. 1.Neurology Department, Division Mazarin, Hôpital de la Salpêtrière, 47 bvd de l’Hôpital, Paris, FranceFR
  2. 2.Laboratory of Neuropathology R. Escourolle, INSERM U360, Association Claude Bernard, Hôpital de la Salpêtrière, 47 bvd de l’Hôpital, F-75651 Paris Cedex 13, France Tel: 33-1-42 16 18 81; Fax: 33-1-44 23 98 28FR
  3. 3.Ludwig Boltzmann Institute of Clinical Neurobiology, Krankenhaus der Stadt Wien-Lainz, Wolkersbergenstrasse 1, A-1130 Vienna, AustriaAT
  4. 4.Neuroepidemiology Branch, NINDS NIH, Federal Bldg, Rm 714, Bethesda, MD 20892, USAUS
  5. 5.INSERM U289 and Federation of Neurology, Hôpital de la Salpêtrière, 47 bvd de l’Hôpital, Paris, FranceFR

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