Acta Neuropathologica

, Volume 100, Issue 6, pp 709–711 | Cite as

Amyloid in a multiple sclerosis lesion is clearly of Aλ type

  • R. Schröder
  • Inger Nennesmo
  • Reinhold P. Linke
Case report


In rare multiple sclerosis cases amyloid is deposited in demyelinated plaques. In one such case amyloid was examined immunohistochemically with a panel of antibodies directed against different amyloid types. The amyloid was classified as the Aλ type produced by a local monoclonal B cell population.

Key words Multiple sclerosis Aλ amyloid Immunohistochemistry 


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Copyright information

© Springer-Verlag Berlin Heidelberg 2000

Authors and Affiliations

  • R. Schröder
    • 1
  • Inger Nennesmo
    • 2
  • Reinhold P. Linke
    • 3
  1. 1.Institute of Pathology, Neuropathology, University of Cologne, Josef-Stelzmann-Strasse 9, 50924 Köln, Germany Fax: +49-221-4786360DE
  2. 2.Division of Pathology, Karolinska Institutet, Huddinge Hospital, Huddinge, SwedenSE
  3. 3.Max-Planck-Institute of Biochemistry, Martinsried, GermanyDE

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