Acta Neuropathologica

, Volume 100, Issue 3, pp 270–274 | Cite as

Fragmentation of the Golgi apparatus of the ballooned neurons in patients with corticobasal degeneration and Creutzfeldt-Jakob disease

  • A. Sakurai
  • K. Okamoto
  • Y. Fujita
  • Y. Nakazato
  • K. Wakabayashi
  • H. Takahashi
  • N. K. Gonatas
Regular paper

Abstract

We investigated immunohistologically the Golgi apparatus (GA) and the trans-Golgi network (TGN) of the cortical ballooned neurons (BNs) in two patients with corticobasal degeneration and in five with Creutzfeldt-Jakob disease. We observed that the BNs showed fragmentation of the GA and the TGN, accompanied by a reduction in the number of fragmented Golgi elements and by a unique perinuclear distribution. This is the first report of the abnormalities of GA in cortical BNs. These findings suggests that the GA and the TGN may play some roles in the BN formation.

Key words Ballooned neuron Golgi apparatus Corticobasal degeneration Creutzfeldt-Jakob disease 

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Copyright information

© Springer-Verlag Berlin Heidelberg 2000

Authors and Affiliations

  • A. Sakurai
    • 1
  • K. Okamoto
    • 1
  • Y. Fujita
    • 1
  • Y. Nakazato
    • 2
  • K. Wakabayashi
    • 3
  • H. Takahashi
    • 4
  • N. K. Gonatas
    • 5
  1. 1.Department of Neurology, Gunma University School of Medicine, Maebashi, Gunma 371-8511, Japan Tel.: +81-27-2208061, Fax: +81-27-2208067JP
  2. 2.Department of Pathology, Gunma University School of Medicine, Maebashi, Gunma 371-8511, JapanJP
  3. 3.Brain Disease Research Center, Brain Research Institute, Niigata University, Niigata 951-8585, JapanJP
  4. 4.Department of Pathology, Brain Research Institute, Niigata University, Niigata 951-8585, JapanJP
  5. 5.Department of Pathology and Laboratory Medicine, 418 Johnson Pavilion, University of Pennsylvania School of Medicine, Philadelphia, PA 19104-6079, USAUS

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