YAP1-fusions in pediatric NF2-wildtype meningioma
Meningioma is the most common primary central nervous system (CNS) tumor . In contrast to adulthood, meningiomas are rare among children and adolescents and frequently (about 38%) occur in the context of tumor predisposition syndromes . In line with the frequent inactivation of NF2 in adult meningiomas, neurofibromatosis type 2 is the most common inherited syndrome predisposing to the early development of meningiomas, which are often multiple. Other germline alterations predisposing to meningioma development are SMARCE1  and SUFU mutations . More recently identified drivers of meningiomas include AKT1/TRAF7, SMO, KLF4/TRAF7, and PIK3CA mutations [3, 5].
We thank L. Dörner and H. Y. Nguyen for skillful technical assistance and the microarray unit of the DKFZ Genomics and Proteomics Core Facility for providing Illumina DNA methylation array-related services. This study was supported by the German Cancer Aid (70112956) and Else Kröner-Fresenius Stiftung (EKFS 2015_A60). FS is a fellow of the Else Kröner Excellence Program of the Else Kröner-Fresenius Stiftung (EKFS 2017_EKES.24).
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