Enteric alpha-synuclein expression is increased in Crohn’s disease
An accumulating body of evidence has emerged in the last decade to suggest that gastrointestinal (GI) inflammation might be involved in the development of Parkinson’s disease (PD). Elevated levels of proinflammatory cytokines  and fecal markers of inflammation have been reported in PD patients . Data from genetic studies further support the close relationship between PD and GI inflammation as PD and Crohn’s disease (CD) share common causative and susceptibility genes such as leucine-rich repeat kinase 2 (LRRK2) and nucleotide-binding oligomerization domain-containing protein 2 (NOD2) (reviewed in ). Two recent large epidemiological studies, by showing an increased risk of subsequent PD in patients with inflammatory bowel disease (IBD) when compared with non-IBD subjects, tie even closer together these two disorders [4, 7].
The mechanisms by which gastrointestinal inflammation might influence PD development or progression are still unclear. A recent report showed that...
This work was supported by a grant from centre d’entraide et de coordination des associations de parkinsoniens (CECAP) and Parkinsonien de Vendée (FFGP) to AP and PD and Institut de France to PD.
AP, AL, ED, GC and MRD performed the experiments. AB, ED, MN and MRD were involved in tissue sampling and biobanking. MRD and PD supervised the study, wrote the first draft and the final version of the manuscript.
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Conflict of interest
The authors declare no actual or potential conflict of interest.