The aftermath of boxing revisited: identifying chronic traumatic encephalopathy pathology in the original Corsellis boxer series
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In 1973, Corsellis and colleagues presented their findings of neuropathological changes in retired boxers in their seminal paper entitled ‘The Aftermath of Boxing’ . The neuropathological changes associated with boxing, such as ventricular dilatation, cavum septum pellucidum and neurofibrillary tangle pathology highlighted by the authors would go on to set the groundwork for our understanding of chronic traumatic encephalopathy (CTE) [2, 3, 4, 9, 10]. In 2016, under the guidance of NINDS/NIBIB, a consensus was reached amongst neuropathologists with expertise in neurodegenerative brain pathologies on the preliminary neuropathological diagnostic criteria for CTE, with a pathognomonic lesion of hyperphosphorylated tau in both neurons and astrocytes around small blood vessels at the base of cortical sulci . Here, we sought to audit the neuropathological diagnosis of the boxers in the Corsellis series using the proposed preliminary criteria for CTE. Employing modern immunohistochemical techniques to tissue sections available from 14 of the original 15 cases, we screened for the deposition of hyperphosphorylated tau. The archival brain tissue from the Corsellis collection has been in fixative since the early 70s and sampled by many researchers over the past 45 years. This has limited the scope of our study and may affect our results in that we did not have access to all recommended regions outlined in the consensus criteria . We therefore sampled multiple sites within the frontal and temporal cortices and systematically examined serial sections from these regions. The available brain regions and immunohistochemical staining applied are summarised in the supplementary tables. Antigen retrieval was performed to optimise staining in tissue fixed for prolonged periods.
The presence of additional tau pathologies is an interesting finding. A recent meta-analysis of 32 studies by Li and colleagues  demonstrated that repetitive head impact (RHI) significantly increases the relative risk of developing dementia and AD; however, recent publications indicate that TBI may not increase the risk of AD . To further complicate the issue, TBI has also been shown to increase the risk for the onset other proteinopathies such as Lewy Body dementia , whilst the presence of multiple proteinopathies in individuals has been associated with advanced age . ARTAG is a newly recognised histological entity with tau accumulation restricted to the glia rather than neurons, commonly observed in older individuals [5, 7]. The overlapping histological features of ARTAG and CTE and the frequent concomitant findings of their features in the same individual raise the question of these two histological entities being on a spectrum of the same disorder.
Our results indicate that not all individuals exposed to RHI from boxing or other high impact sports inevitably develop CTE pathology. RHI may not be sufficient on its own to lead to CTE. It is possible that environmental and genetic risk or protective factors may also play a role in the onset of CTE pathology.
- 1.Adams JW, Alvarez VE, Mez J, Huber BR, Tripodis Y, Xia W, Meng G, Kubilus CA, Cormier K, Kiernan PT et al (2018) Lewy body pathology and chronic traumatic encephalopathy associated with contact sports. J Neuropathol Exp Neurol 77:757–768. https://doi.org/10.1093/jnen/nly065 CrossRefPubMedPubMedCentralGoogle Scholar
- 8.McKee AC, Cairns NJ, Dickson DW, Folkerth RD, Keene CD, Litvan I, Perl DP, Stein TD, Vonsattel JP, Stewart W et al (2016) The first NINDS/NIBIB consensus meeting to define neuropathological criteria for the diagnosis of chronic traumatic encephalopathy. Acta Neuropathol 131:75–86. https://doi.org/10.1007/s00401-015-1515-z CrossRefPubMedGoogle Scholar
- 9.McKee AC, Cantu RC, Nowinski CJ, Hedley-Whyte ET, Gavett BE, Budson AE, Santini VE, Lee HS, Kubilus CA, Stern RA (2009) Chronic traumatic encephalopathy in athletes: progressive tauopathy after repetitive head injury. J Neuropathol Exp Neurol 68:709–735. https://doi.org/10.1097/NEN.0b013e3181a9d503 CrossRefPubMedPubMedCentralGoogle Scholar
- 11.Robinson JL, Lee EB, Xie SX, Rennert L, Suh E, Bredenberg C, Caswell C, Van Deerlin VM, Yan N, Yousef A et al (2018) Neurodegenerative disease concomitant proteinopathies are prevalent, age-related and APOE4-associated. Brain 141:2181–2193. https://doi.org/10.1093/brain/awy146 CrossRefPubMedGoogle Scholar
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