Chordoid meningiomas can be sub-stratified into prognostically distinct DNA methylation classes and are enriched for heterozygous deletions of chromosomal arm 2p
Chordoid meningioma represents a rare meningioma variant. It is histologically defined by the presence of trabeculae of eosinophilic and vacuolated epithelioid cells within a mucin-rich stroma . The term chordoid meningioma was first used by Kepes et al. in 1988 , who published a series of seven cases. In a subsequent larger series of 42 cases, a considerable risk of recurrence even after total resection was identified . Based on these findings, chordoid meningiomas are per definition graded as WHO grade II .
For several variants of meningioma, associations with distinct genetic events have been identified. Examples are KLF4/TRAF7 mutations in secretory meningioma, enrichment for AKT1 mutations in meningothelial meningioma, SMARCE1 mutations in clear cell meningioma, and BAP1 mutation or deletion in rhabdoid meningioma [2, 3, 9, 11, 12]. So far, no distinct mutation has been identified for chordoid meningioma. Also, no unique DNA methylation pattern has been found for...
This work was supported by the Else Kröner-Fresenius Stiftung (2015_A60 and 2107_EKES.24) and the German Cancer Aid (110983, 111670 and 70112956). We thank Laura Dörner and Hai Yen Nguyen for skillful technical assistance.